The effects of ketogenic diet with resistance training on the serum levels of some adipokines in obese women
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شناسه دیجیتال (DOI): 10.22089/ssrc.2024.4120
کد مقاله : 1064-SSRC
نویسندگان
Department of Exercise Physiology, Ilam Branch, Islamic Azad University, Ilam, Iran
چکیده
Background & Objective: Diet and exercise training are suggested methods to reduce obesity- induced complications. Ketogenic diet (KD) included a diet with a high amount of fat, normal protein and very low carbohydrate intake. Although this diet provides enough calories and protein, but it causes chronic ketosis in the body. Also, KD changes the source of energy from glucose to fatty acid by limiting the availability of glucose. Data show that, this diet helps to improve hyperinsulinemia and body composition. Resistance training (RT) with a direct effect on muscle mass increases basal metabolism and decreases body fat mass. Adipose tissue is an endocrine organ that secretes large amounts of active molecules called adipokines. Adipokines have important effects on the total energy balance of the body. The purpose of the present study was to determine the effects of KD with RT on the serum levels of some adipokines in obese women.
Methodology: In this semi-experimental study, 38 middle-aged women with BMI= 33.4±2.8 kg/m2 volunteered to participate that randomly divided into KD (n=10), RT (n=9), KD+ RT (n=10) and control (n=9) groups. The interventions comprised a 8-week KD, RT and a combined approach with three sessions per week. The circulating adipokines [Semaphorin-3C (Sema3C), tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6)] levels were assessed within 48 h of the before and final training session.
Findings: Statistical analyses revealed significant differences across all measures among the groups (p<0.05). The KD+ RT approach led to significantly reductions in Sema3C, TNF-α and IL-6 levels levels relative to the other groups (all; p<0.019). Furthermore, Sema3C and TNF-α levels significantly declined in RT rather than KD and control groups (both; p<0.042). Ultimately, in comparison to control Sema3C and TNF-α levels significantly decreased in KD group (both; p<0.034).
Conclusion: The results of this study demonstrate that, KD in conjunction with RT reduced adipokine levels and improved body fat percentage. This investigation confirmed the potential of KD and RT as a synergistic strategy to ameliorate obesity-related complications in obese women.
Methodology: In this semi-experimental study, 38 middle-aged women with BMI= 33.4±2.8 kg/m2 volunteered to participate that randomly divided into KD (n=10), RT (n=9), KD+ RT (n=10) and control (n=9) groups. The interventions comprised a 8-week KD, RT and a combined approach with three sessions per week. The circulating adipokines [Semaphorin-3C (Sema3C), tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6)] levels were assessed within 48 h of the before and final training session.
Findings: Statistical analyses revealed significant differences across all measures among the groups (p<0.05). The KD+ RT approach led to significantly reductions in Sema3C, TNF-α and IL-6 levels levels relative to the other groups (all; p<0.019). Furthermore, Sema3C and TNF-α levels significantly declined in RT rather than KD and control groups (both; p<0.042). Ultimately, in comparison to control Sema3C and TNF-α levels significantly decreased in KD group (both; p<0.034).
Conclusion: The results of this study demonstrate that, KD in conjunction with RT reduced adipokine levels and improved body fat percentage. This investigation confirmed the potential of KD and RT as a synergistic strategy to ameliorate obesity-related complications in obese women.
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