The Effect of Aerobic Training on Microvascular Dysfunction:

Poster Presentation
Paper ID : 1134-SSRC
Authors
دانشگاه رازی
Abstract
Introduction: Microvascular dysfunction is a multifaceted condition characterized by impaired function of the small blood vessels, leading to compromised blood flow and tissue perfusion. While numerous studies have explored the impact of various interventions on microvascular dysfunction, the potential benefits of aerobic training remain largely unexplored.

Methods: A systematic search of electronic databases was conducted to identify relevant studies published between 2000 and 2023. The search strategy included keywords related to aerobic training, microvascular dysfunction, and associated outcomes. The review identified a total of 45 studies that met the inclusion criteria. These studies encompassed a diverse range of populations, including individuals with cardiovascular diseases, metabolic disorders, and sedentary lifestyles. Various measures of microvascular dysfunction, such as endothelial function, capillary density, and microcirculatory blood flow, were assessed using state-of-the-art techniques like laser Doppler flowmetry, reactive hyperemia, and brachial artery flow-mediated dilation.
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Results: The findings from the reviewed studies indicate a consistent and positive effect of aerobic training on microvascular dysfunction. Aerobic training interventions, including moderate-intensity continuous training, high-intensity interval training, and combined aerobic and resistance training, demonstrated improvements in microvascular function across different populations. These improvements were observed through enhanced endothelial function, increased capillary density, and improved microcirculatory blood flow. Furthermore, the review highlights potential underlying mechanisms contributing to the beneficial effects of aerobic training on microvascular dysfunction. These mechanisms include improved nitric oxide bioavailability, reduced oxidative stress, enhanced angiogenesis, and favorable changes in metabolic profiles.

Conclusion: This comprehensive review provides evidence that aerobic training exerts a positive effect on microvascular dysfunction. These findings have important implications for the prevention and management of conditions associated with microvascular dysfunction. Future research should focus on elucidating optimal training protocols, long-term effects, and potential synergistic effects of aerobic training with other interventions.
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