The Effect of Aerobic Training on Liver Enzymes, Lipid Profile, and Insulin Sensitivity in Rats with Type 2 Diabetes: A Comprehensive Review
Poster Presentation
Paper ID : 1149-SSRC
Authors
1دانشجوی دکترای تخصصی دانشگاه رازی دانشکده تربیت بدنی و علوم ورزشی
2استاد یار دانشگاه رازی
Abstract
Background: Type 2 Diabetes Mellitus (T2DM) is a chronic metabolic disorder characterized by insulin resistance and impaired glucose regulation. It is associated with dysregulation of various metabolic parameters, including liver enzymes, lipid profile, and insulin sensitivity. Aerobic exercise has been widely recognized as an effective non-pharmacological intervention for managing T2DM. This review aims to explore the underlying cellular and molecular signaling pathways involved in the effect of aerobic training on liver enzymes, lipid profile, and insulin sensitivity in rats with T2DM.
Methods: A systematic search of electronic databases, including PubMed, Scopus, and Web of Science, was conducted to identify relevant studies published between 2000 and 2023. The keywords used in the search included "aerobic exercise," "type 2 diabetes," "liver enzymes," "lipid profile," and "insulin sensitivity." Only studies conducted on rat models of T2DM were included. The selected studies were evaluated for study design, sample size, intervention duration, exercise protocols, and outcome measures.
Results: Aerobic training has demonstrated significant beneficial effects on liver enzymes, lipid profile, and insulin sensitivity in rats with T2DM. Aerobic exercise increases the expression and activity of hepatic antioxidant enzymes, such as dismutase and catalase, leading to a reduction in oxidative stress and improved liver function. It also promotes the activation of AMP-activated protein kinase (AMPK) and peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α), which enhances mitochondrial biogenesis and improves lipid metabolism. Additionally, aerobic training enhances insulin signaling and glucose uptake in skeletal muscle, leading to improved insulin sensitivity.
Conclusion: Aerobic training exerts profound effects on liver enzymes, lipid profile, and insulin sensitivity in rats with T2DM. The underlying cellular and molecular signaling pathways involved include antioxidative stress mechanisms, mitochondrial biogenesis, and enhanced insulin signaling. These findings highlight the potential of aerobic exercise as a therapeutic strategy for managing T2DM and its associated metabolic abnormalities. But more studies are necessary for clinical practice for the benefit of individuals with T2DM.
Methods: A systematic search of electronic databases, including PubMed, Scopus, and Web of Science, was conducted to identify relevant studies published between 2000 and 2023. The keywords used in the search included "aerobic exercise," "type 2 diabetes," "liver enzymes," "lipid profile," and "insulin sensitivity." Only studies conducted on rat models of T2DM were included. The selected studies were evaluated for study design, sample size, intervention duration, exercise protocols, and outcome measures.
Results: Aerobic training has demonstrated significant beneficial effects on liver enzymes, lipid profile, and insulin sensitivity in rats with T2DM. Aerobic exercise increases the expression and activity of hepatic antioxidant enzymes, such as dismutase and catalase, leading to a reduction in oxidative stress and improved liver function. It also promotes the activation of AMP-activated protein kinase (AMPK) and peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α), which enhances mitochondrial biogenesis and improves lipid metabolism. Additionally, aerobic training enhances insulin signaling and glucose uptake in skeletal muscle, leading to improved insulin sensitivity.
Conclusion: Aerobic training exerts profound effects on liver enzymes, lipid profile, and insulin sensitivity in rats with T2DM. The underlying cellular and molecular signaling pathways involved include antioxidative stress mechanisms, mitochondrial biogenesis, and enhanced insulin signaling. These findings highlight the potential of aerobic exercise as a therapeutic strategy for managing T2DM and its associated metabolic abnormalities. But more studies are necessary for clinical practice for the benefit of individuals with T2DM.
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