Poster Presentation

Paper ID : 1164-SSRC

¹Assistant Professor of Motor Development, Department of Sport Science, Faculty of Humanities, Bojnourd Branch, Islamic Azad University, Bojnourd, Iran

²M.Sc. in Exercise Physiology, Department of Sport Science, Bojnourd Branch, Islamic Azad University, Bojnourd, Iran.

Background: Obesity is one of the risk factors for many metabolic disorders. Adipose tissue is not only a source of energy storage, but it also synthesizes and secretes important metabolic proteins, including adipokines. These proteins can regulate several biological actions. New adipokines such as Semaphorin and its receptor Plexin are associated with obesity and type 2 diabetes. Plexin D1 belongs to the Plexins family and can act as a tumor promoter and suppressor. Also, mutations in Plexin D1 can lead to serious cardiovascular diseases. Plexin D1 can act as an activating protein and modulate integrin-mediated cell adhesion, cytoskeleton dynamics, and cell migration. These effects may play a regulatory role in developing the cardiovascular system and disease. The present study aimed to investigate the effect of eight weeks of Aquatic training and resistance training on the expression of Plexin D1 receptors and biochemical indicators in aged male rats with a high-fat diet. METHODS: 30 elderly male Wistar rats with age (20-22 months) and weight (250±20) were selected by random sampling, and were divided into three groups; obese-non active rats, resistance training group, and Aqua training group (n=10). The aquatic training protocol included five sessions per week 20 min of activity and 10 sec of rest in a rat pool. Resistance training protocol consists of five sessions per week on the ladder, and the rats will have to perform ten repetitions with the target weight. Blood samplings were gathered 48 hours after the last training session. Data analysis was performed using ANOVA, and the Eta-squared test. RESULTS: The ANOVA results showed an increase in Plexin D1 (F=2.19, p=0.131, η2 =0.140) among exercise groups, but it was not significant. Also, Fast Blood Sugar (F=2.69, p=0.086), and Insulin (F=0.616, p=0.547) did not show significant changes among groups. Moreover, the Pearson correlation coefficient test showed that there is not a strong relationship between PlexinD1 and FBS=(r=-0.089, p=0.641), and Insulin= (r=-0.012, p=0.949). CONCLUSION: Although periodic and regular training can decrease the serum levels of Plexin D1 and biochemical indicators in obese middle-aged rats, in this study, the changes were not significant.

training; Plexin D1; Elderly rats