"The effect of functional training and L- citrulline supplementation on brain-derived neurotrophic serum levels And neuroconduction indices in people with type 2 diabetes"
Poster Presentation
Paper ID : 1239-SSRC
Authors
1آموزش و پرورش
2عضو هیئت علمی دانشگاه خوارزمی
Abstract
Abstract:
Objective: Considering type 2 diabetes leads to impaired glycemic index and gradually impaired nerve conduction, the present study aimed to determine the effect of regular functional training and L-citrulline supplementation on glycemic control, the level of nerve growth factor derived from Brain (BDNF)and nerve conduction indexes(NCI) were assessed in patients with type 2 diabetes..
Methodology: In study, 16 type 2 diabetics patients with 8.59 years were randomly divided into 3 groups: control(G1), functional training(G2), and functional training with L-citrulline supplementation(G3). The functional training program included (8 weeks - 4 sessions per week) home base training. L-citrulline supplementation was administered 45 minutes before each training session with a dose of 8 g in 250 ml of water. Nerve conduction velocity(NCV) and amplitude of action potential of median and sural sensory nerves and median and tibial motor nerves, surface electromyography due to maximal voluntary isometric contraction(MVIC) of Biceps and Gastrocnemius muscles , BDNF and serum nitric oxide (NO) were measured before and after 8 week functional training and supplementation interventions. Data were analyzed using analysis of variance and Bonferroni post hoc test (P≥0.005).
Results: There was a significant decrease in the level of insulin resistance in the (G2,G3) compared to the (G1). Significant increase was observed in serum BDNF and NO (nitrite and nitrate), Median and Sural sensory NCV and amplitude Sural sensory and median motor in potential. However, there was a significant difference in the NCV of the median and tibial motor nerve , amplitude of the median sensory nerve and the tibial motor nerve between the (G3) with the (G1). Surface electromyography due to MVIC of Biceps and Gastrocnemius muscles was significantly different in the (G2,G3) compared to the (G1).
Conclusion: The results of the this study showed that eight weeks of functional training with L-citrulline supplementation controls blood sugar, reduces insulin resistance, increases BDNF, NO, NCI and improves neuromuscular function in patients with type 2 diabetes that could indicate the positive role of functional training with L-citrulline supplementation in controlling blood sugar and preventing neuromuscular complications and improving neuromuscular function in patients with type 2 diabetes.
Objective: Considering type 2 diabetes leads to impaired glycemic index and gradually impaired nerve conduction, the present study aimed to determine the effect of regular functional training and L-citrulline supplementation on glycemic control, the level of nerve growth factor derived from Brain (BDNF)and nerve conduction indexes(NCI) were assessed in patients with type 2 diabetes..
Methodology: In study, 16 type 2 diabetics patients with 8.59 years were randomly divided into 3 groups: control(G1), functional training(G2), and functional training with L-citrulline supplementation(G3). The functional training program included (8 weeks - 4 sessions per week) home base training. L-citrulline supplementation was administered 45 minutes before each training session with a dose of 8 g in 250 ml of water. Nerve conduction velocity(NCV) and amplitude of action potential of median and sural sensory nerves and median and tibial motor nerves, surface electromyography due to maximal voluntary isometric contraction(MVIC) of Biceps and Gastrocnemius muscles , BDNF and serum nitric oxide (NO) were measured before and after 8 week functional training and supplementation interventions. Data were analyzed using analysis of variance and Bonferroni post hoc test (P≥0.005).
Results: There was a significant decrease in the level of insulin resistance in the (G2,G3) compared to the (G1). Significant increase was observed in serum BDNF and NO (nitrite and nitrate), Median and Sural sensory NCV and amplitude Sural sensory and median motor in potential. However, there was a significant difference in the NCV of the median and tibial motor nerve , amplitude of the median sensory nerve and the tibial motor nerve between the (G3) with the (G1). Surface electromyography due to MVIC of Biceps and Gastrocnemius muscles was significantly different in the (G2,G3) compared to the (G1).
Conclusion: The results of the this study showed that eight weeks of functional training with L-citrulline supplementation controls blood sugar, reduces insulin resistance, increases BDNF, NO, NCI and improves neuromuscular function in patients with type 2 diabetes that could indicate the positive role of functional training with L-citrulline supplementation in controlling blood sugar and preventing neuromuscular complications and improving neuromuscular function in patients with type 2 diabetes.
Keywords