the effect of exercise training on the levels of some hepatokines in people with type 2 diabetes e: A Literature Review
Poster Presentation
Paper ID : 1261-SSRC
Authors
1Professor in Exercise Physiology, Faculty of Sport Sciences, Department of Exercise Physiology, University of Isfahan, Isfahan, Iran
2گروه علوم ورزشی، دانشکده علوم انسانی و اجتماعی، دانشگاه اردکان، اردکان، ایران
3, Faculty of Sport Sciences, Department of Exercise Physiology, University of Isfahan, Isfahan, Iran
Abstract
Abstract:
background: Hepatokines include cytokines and other peptides that are produced and released by the liver and can affect metabolic processes through autocrine, paracrine and endocrine signaling.
Objective: Therefore, the aim of this review was to investigate the effect of exercise training on the levels of hepatokine in people with with type 2 diabetes
Methods & Materials: Springer, PubMed, Elsevier, SID and Google Scholar databases were used in the review and narrative study from 2009 to 2023. Also, the keywords "Physical fitness, physical activity, exercise, liver, hepatokine, LECT2, ANGPTL6, FGF21, Hepassocin, fetuin-A and fetuin-B" were used in the search. After the initial screening, the full text of the articles was evaluated and the articles that met the inclusion criteria were analyzed. 67 articles met the inclusion criteria for the review study.
Results: Recent research shows that metabolic diseases of diabetes lead to increased levels of hepatokines ANGPTL6, FGF21, Hepassocin, fetuin-A and fetuin-B. Research shows that exercise may reduce the levels of these hepatokines in people with diabetes. The mechanism of hepatokine alteration can be explained as chronic positive energy balance, and obesity-related metabolic disease have been shown to modulate liver protein synthesis and hepatokine secretion. recent research shows that hepatokines are sensitive to acute disturbances in energy and substrate metabolism because they coordinate metabolic responses between the liver and extrahepatic tissues. hepatokines play a role in coordinating metabolic responses to fasting and feeding. The release of hepatokines may be modulated due to metabolic changes in exercise. Potentially, acute metabolic benefits associated with physical activity, such as improved whole-body substrate metabolism and insulin sensitivity, may lead to decreased hepatokine secretion.
Conclusions: Considering the beneficial effects of exercise training (resistance and endurance) on hepatokines, it seems that the intervention of exercise training has an effective therapeutic effect on the hepatic hepatokines of diabetics.
KeyWords: exercise training, hepatokine, type 2 diabetes
background: Hepatokines include cytokines and other peptides that are produced and released by the liver and can affect metabolic processes through autocrine, paracrine and endocrine signaling.
Objective: Therefore, the aim of this review was to investigate the effect of exercise training on the levels of hepatokine in people with with type 2 diabetes
Methods & Materials: Springer, PubMed, Elsevier, SID and Google Scholar databases were used in the review and narrative study from 2009 to 2023. Also, the keywords "Physical fitness, physical activity, exercise, liver, hepatokine, LECT2, ANGPTL6, FGF21, Hepassocin, fetuin-A and fetuin-B" were used in the search. After the initial screening, the full text of the articles was evaluated and the articles that met the inclusion criteria were analyzed. 67 articles met the inclusion criteria for the review study.
Results: Recent research shows that metabolic diseases of diabetes lead to increased levels of hepatokines ANGPTL6, FGF21, Hepassocin, fetuin-A and fetuin-B. Research shows that exercise may reduce the levels of these hepatokines in people with diabetes. The mechanism of hepatokine alteration can be explained as chronic positive energy balance, and obesity-related metabolic disease have been shown to modulate liver protein synthesis and hepatokine secretion. recent research shows that hepatokines are sensitive to acute disturbances in energy and substrate metabolism because they coordinate metabolic responses between the liver and extrahepatic tissues. hepatokines play a role in coordinating metabolic responses to fasting and feeding. The release of hepatokines may be modulated due to metabolic changes in exercise. Potentially, acute metabolic benefits associated with physical activity, such as improved whole-body substrate metabolism and insulin sensitivity, may lead to decreased hepatokine secretion.
Conclusions: Considering the beneficial effects of exercise training (resistance and endurance) on hepatokines, it seems that the intervention of exercise training has an effective therapeutic effect on the hepatic hepatokines of diabetics.
KeyWords: exercise training, hepatokine, type 2 diabetes
Keywords