Exercise training attenuates liver fat accumulation and improves insulin resistance in children and adolescents: a systematic review and meta-analysis
Poster Presentation
Paper ID : 1290-SSRC
Authors
1دانشگاه کاشان دانشکده علوم انسانی گروه علوم ورزشی
2University of Kashan
Abstract
Background. The prevalence of obesity in children and adolescents is associated with the accumulation of liver fat which is linked with insulin resistance. Therefore, the purpose of this meta-analysis is to investigate the effect of exercise training on liver fat accumulation and insulin resistance in children and adolescents individuals with overweight and obesity.
Method. A comprehensive search was conducted in PubMed, Web of Science, Google Scholar, Magiran, and Noormags databases from the inception to January 21, 2023. The inclusion criteria for the present meta-analysis included 1) children and adolescents, 2) exercise training, 3) overweight and obesity, 4)studies with a control group or with values measured in the pre-test stage and 4) liver fat as the main variable. To calculate the effect size, standardized mean differences (SMD), weighted mean differences (WMD) and 95% confidence intervals (CIs) were calculated using the random effect model for the comparing the effect of exercise training versus control. Also, I2 test was used to evaluate heterogeneity and Egger's test and visual interpretation of funnel plot were used to assesses publication bias.
Results. A total, nine studies with eighteen exercise interventions and including 621 children and adolescent were included in the meta-analysis. Exercise result in a decrease in liver fat with a large effect size [SMD: -0.85 (CI: -1.26 to -0.43), p=0.001] and insulin resistance with moderate effect size [WMD: -0.61 (CI: -1.06 to -0.17), p=0.007].
Conclusion. Exercise training results in the reduction of liver fat accumulation and improvement of insulin resistance in children and adolescents with overweight and obesity, which is recommended as a main strategy to reduce liver fat and improve metabolism.
Method. A comprehensive search was conducted in PubMed, Web of Science, Google Scholar, Magiran, and Noormags databases from the inception to January 21, 2023. The inclusion criteria for the present meta-analysis included 1) children and adolescents, 2) exercise training, 3) overweight and obesity, 4)studies with a control group or with values measured in the pre-test stage and 4) liver fat as the main variable. To calculate the effect size, standardized mean differences (SMD), weighted mean differences (WMD) and 95% confidence intervals (CIs) were calculated using the random effect model for the comparing the effect of exercise training versus control. Also, I2 test was used to evaluate heterogeneity and Egger's test and visual interpretation of funnel plot were used to assesses publication bias.
Results. A total, nine studies with eighteen exercise interventions and including 621 children and adolescent were included in the meta-analysis. Exercise result in a decrease in liver fat with a large effect size [SMD: -0.85 (CI: -1.26 to -0.43), p=0.001] and insulin resistance with moderate effect size [WMD: -0.61 (CI: -1.06 to -0.17), p=0.007].
Conclusion. Exercise training results in the reduction of liver fat accumulation and improvement of insulin resistance in children and adolescents with overweight and obesity, which is recommended as a main strategy to reduce liver fat and improve metabolism.
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