Remote ischemic preconditioning has synergetic effect with resistance and endurance training in ameliorate some metabolic parameters in Wistar diabetic rats
Poster Presentation
Paper ID : 1298-SSRC
Authors
1Department of Exercise Physiology, Humanity Faculty, Sari Islamic Azad University
2department of exercise physiology, humanity faculty, Sari Azad Islamic University
3department of exercise physiology, Humanity Faculty, Sari Azad Islamic University
Abstract
Background: Ischemic preconditioning (IPC) involves a brief period of sublethal local tissue ischemia that confers protection against a subsequent lethal ischemia. IPC has been used to improve exercise performance, but the effect of IPC on diabetes is still unclear. The purpose of this study was to determine the effect of IPC with resistance and aerobic training on some metabolic parameters in diabetic Rats.
Methods: forty-two Wister rats (288 ± 22 g) were randomly divided into eight groups: non-diabetic control (C), diabetic control (DC), diabetic sham, diabetic IPC (DI), diabetic resistance training (DR), diabetic endurance training (DE), diabetic IPC+resistance training (DIR), diabetic IPC+endurance training (DIE). Diabetes was induced using streptozotocin. IPC was induced by three cycles of 5-minute ischemia/5-minute reperfusion of bilateral hind limbs 20 min prior exercise. For this, bilateral proximal hind limbs were encircled with rubber bands. The training protocols were performed five days a week for six weeks. The resistance training included going up a ladder with weights attached to the tail that gradually increased. Endurance training included running on treadmill. Plasma glucose and insulin levels were measured and HOMA-IR was calculated. Independent t test and two-way ANOVA were used to analyze data.
Results: diabetes increased the levels of glucose and HOMA-IR, but significantly reduced insulin. The glucose and insulin resistance index were significantly decreased in the DE, DIR and DI than DC (p<0.05), So that the reduction was more in the DIR and DIE. There was no effect on the level of insulin serum level.
Conclusion: It seems that performing the endurance and resistance training with remote ischemic preconditioning is more effective in ameliorating some metabolic
parameters than any of these interventions alone in diabetes.
Methods: forty-two Wister rats (288 ± 22 g) were randomly divided into eight groups: non-diabetic control (C), diabetic control (DC), diabetic sham, diabetic IPC (DI), diabetic resistance training (DR), diabetic endurance training (DE), diabetic IPC+resistance training (DIR), diabetic IPC+endurance training (DIE). Diabetes was induced using streptozotocin. IPC was induced by three cycles of 5-minute ischemia/5-minute reperfusion of bilateral hind limbs 20 min prior exercise. For this, bilateral proximal hind limbs were encircled with rubber bands. The training protocols were performed five days a week for six weeks. The resistance training included going up a ladder with weights attached to the tail that gradually increased. Endurance training included running on treadmill. Plasma glucose and insulin levels were measured and HOMA-IR was calculated. Independent t test and two-way ANOVA were used to analyze data.
Results: diabetes increased the levels of glucose and HOMA-IR, but significantly reduced insulin. The glucose and insulin resistance index were significantly decreased in the DE, DIR and DI than DC (p<0.05), So that the reduction was more in the DIR and DIE. There was no effect on the level of insulin serum level.
Conclusion: It seems that performing the endurance and resistance training with remote ischemic preconditioning is more effective in ameliorating some metabolic
parameters than any of these interventions alone in diabetes.
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