The Effect of resistance/endurance training on biomarkers of neuronal dysfunction in hippocampal tissue and cognitive function in elderly diabetic rats
Poster Presentation
Paper ID : 1318-SSRC
Authors
1University of Isfahan
2Professor in Exercise Physiology, Faculty of Sport Sciences, Department of Exercise Physiology, University of Isfahan, Isfahan, Iran
Abstract
Background: Changes in biomarkers of neuronal have been shown to be crucial in the process of cognitive dysfunction in type 2 diabetes (T2D). Exercise training has effect in increasing cognitive function mediated by Biomarkers of neuronal.
Objective: It is known that exercise can affect the brain and cognition through different levels of mechanisms in the lifespan. It has been shown that the molecules of visinin-like protein 1 (Vilip-1) and neurogranin (Ng) play a role in neuronal dysfunction process. Our aim is to investigate the role of resistance/endurance training on this molecules in Hippocampal Tissue and Cognitive Function in Elderly Diabetic Rats.
Methods: thirty-two-old male Wistar rats were randomly assigned into four groups, including healthy control (Control), diabetic control (DM), resistance training (RT), and endurance training (ET). Streptozotocin (STZ) (Single dosage; 30 mg/kg, i.p.) and HFD (fats (55%), carbohydrates (31%), and protein (14%) were used to induce diabetes. Then, ET (60-75% of vVO2max intensity/5day/week) and RT (60% of the MVCC, 14-20 climbs/5day/week) were administered for eight weeks. Cognitive-motor functioning was assessed through open-field test and was analyzed by western blot method for the concentration of neurogranin (Ng) and visinin-like protein-1 (VILIP-1) in hippocampus tissue.
Results: In addition, the results demonstrated that resistance training significantly decrease biomarkers of Ng (P < 0.001) and VILIP-1, (P < 0.001) compared to control rats. Moreover, improved spatial memory in endurance training (P < 0.001) compared to control group.
Conclusions: This is the first intervention study in type 2 diabetes that shows that exercise training significantly improves brain function through biomarkers of neuronal. Exercise training especially resistance training is an inexpensive treatment with substantial preventative and restorative properties for cognitive and memory brain function in type 2 diabetes.
Objective: It is known that exercise can affect the brain and cognition through different levels of mechanisms in the lifespan. It has been shown that the molecules of visinin-like protein 1 (Vilip-1) and neurogranin (Ng) play a role in neuronal dysfunction process. Our aim is to investigate the role of resistance/endurance training on this molecules in Hippocampal Tissue and Cognitive Function in Elderly Diabetic Rats.
Methods: thirty-two-old male Wistar rats were randomly assigned into four groups, including healthy control (Control), diabetic control (DM), resistance training (RT), and endurance training (ET). Streptozotocin (STZ) (Single dosage; 30 mg/kg, i.p.) and HFD (fats (55%), carbohydrates (31%), and protein (14%) were used to induce diabetes. Then, ET (60-75% of vVO2max intensity/5day/week) and RT (60% of the MVCC, 14-20 climbs/5day/week) were administered for eight weeks. Cognitive-motor functioning was assessed through open-field test and was analyzed by western blot method for the concentration of neurogranin (Ng) and visinin-like protein-1 (VILIP-1) in hippocampus tissue.
Results: In addition, the results demonstrated that resistance training significantly decrease biomarkers of Ng (P < 0.001) and VILIP-1, (P < 0.001) compared to control rats. Moreover, improved spatial memory in endurance training (P < 0.001) compared to control group.
Conclusions: This is the first intervention study in type 2 diabetes that shows that exercise training significantly improves brain function through biomarkers of neuronal. Exercise training especially resistance training is an inexpensive treatment with substantial preventative and restorative properties for cognitive and memory brain function in type 2 diabetes.
Keywords