A meta-analysis of pro-inflammatory cytokine response to exercise training in Patients with Multiple sclerosis
Poster Presentation
Paper ID : 1335-SSRC
Authors
1دانشگاه کاشان
2دانشگاه کاشان دانشکده علوم انسانی گروه علوم ورزشی
Abstract
Background: Multiple sclerosis (MS) is a progressive inflammatory and demyelinating disease of the central nervous system which Inflammatory mediators such as cytokines may play an important role in the pathogenesis and development of this disease. Among these cytokines, tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6) are the most well-known and widely used cytokines to evaluate the state of systemic inflammation as well as the onset, prevalence and progression of MS. In contrast, the available scientific evidence indicates that exercise training has the potential to improve the components related to the pathogenesis and consequences of MS disease, as well as improving chronic inflammation. On the other hand, the disturbance in the inflammatory balance towards the expansion of the pro-inflammatory state is the main characteristic of MS disease, which may be a potential target for adjustment through exercise training. However, the effect of exercise training on inflammatory markers is not clearly understood. Therefore, the purpose of this meta-analysis is to investigate the effect of exercise training on inflammatory cytokines i.e. IL-6 and TNF-α in patients with MS.
Methods: A comprehensive search was conducted in the three main databases of PubMed, Web of Science and Scopus for English and Persian articles published until December 22, 2022. To determine the effect sizes of the effect of exercise training on inflammatory markers IL-6 and TNF-α, standardized mean difference (SMD) and 95% confidence intervals (CIs) were used.
Findings: Thirteen studies involving 607 subjects with MS were included in the meta-analysis. Exercise training resulted in a significant decrease in levels of IL-6 [p=0.002, (CI: -0.14 to 0.65: -0.40)] but on the levels of TNF-α [p=0.20, (0.14 to 0.68 CI: -) -0.27] had no significant effect.
Conclusion: Exercise training may lead to improvement of chronic inflammation status by reducing IL-6 in MS patients. Therefore, prescribing regular exercise for MS patients may be a suitable approach for disease management in these individuals.
Keywords: “Exercise training” , “Cytokines “, “ Inflammation” , “IL-6 , “TNF-α” , “Multiple sclerosis”
Methods: A comprehensive search was conducted in the three main databases of PubMed, Web of Science and Scopus for English and Persian articles published until December 22, 2022. To determine the effect sizes of the effect of exercise training on inflammatory markers IL-6 and TNF-α, standardized mean difference (SMD) and 95% confidence intervals (CIs) were used.
Findings: Thirteen studies involving 607 subjects with MS were included in the meta-analysis. Exercise training resulted in a significant decrease in levels of IL-6 [p=0.002, (CI: -0.14 to 0.65: -0.40)] but on the levels of TNF-α [p=0.20, (0.14 to 0.68 CI: -) -0.27] had no significant effect.
Conclusion: Exercise training may lead to improvement of chronic inflammation status by reducing IL-6 in MS patients. Therefore, prescribing regular exercise for MS patients may be a suitable approach for disease management in these individuals.
Keywords: “Exercise training” , “Cytokines “, “ Inflammation” , “IL-6 , “TNF-α” , “Multiple sclerosis”
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