The Effect of exercise training on CTRP3 levels in adults with metabolic disorders: a systematic review with meta-analysis
Poster Presentation
Paper ID : 1342-SSRC
Authors
دانشگاه کاشان
Abstract
Background and purpose: Adipose tissue, as an important metabolic organ, controls inflammatory responses through the secretion of pro-inflammatory and anti-inflammatory cytokines. Adipokines secreted from adipose tissue have pro-inflammatory effects including TNF-α and anti-inflammatory effects including CTRP3. CTRP3 is an anti-inflammatory adipokine that is reduced in obese people and those with metabolic disorders. Exercise training can increase anti-inflammatory adipokines, but the effect of exercise on CTRP3 levels is unclear. Therefore, this systematic review and meta-analysis aimed to investigate the effect of exercise training on circulating CTRP3 levels in adults with metabolic disorders. Methods: Articles were searched in databases including Pubmed, Web of science until October 2022 using keywords ((sports training)) and ((CTRP3)). The inclusion criteria for the current research included human studies with metabolic disorders, exercise training intervention, and circulating CTRP3 levels. Standardized mean difference (SMD) and 95% confidence interval were calculated using random method.
Results: Based on the search conducted in the databases, 345 articles were entered into And note, after removing duplicates and articles based on the inclusion criteria, finally, 9 articles including 12 exercise interventions and 365 participant with metabolic disorders were included in the meta-analysis. The pooled SMD showed that exercise training significantly increased CTRP3 levels by 0.57 (95% CI: 0.10 to 1.03, P=0.03). There was high and significant heterogeneity among the studies (I2: 84.59%, P<0.001) and evidence of publication bias (Egger's test, P<0.001)
Conclusion: Exercise training has a moderate and positive effect on circulating CTRP3 levels in adults with metabolic disorders. CTRP3 may mediate the anti-inflammatory and insulin-sensitizing effects of exercise training in this population.
Results: Based on the search conducted in the databases, 345 articles were entered into And note, after removing duplicates and articles based on the inclusion criteria, finally, 9 articles including 12 exercise interventions and 365 participant with metabolic disorders were included in the meta-analysis. The pooled SMD showed that exercise training significantly increased CTRP3 levels by 0.57 (95% CI: 0.10 to 1.03, P=0.03). There was high and significant heterogeneity among the studies (I2: 84.59%, P<0.001) and evidence of publication bias (Egger's test, P<0.001)
Conclusion: Exercise training has a moderate and positive effect on circulating CTRP3 levels in adults with metabolic disorders. CTRP3 may mediate the anti-inflammatory and insulin-sensitizing effects of exercise training in this population.
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