Cognitive Boost: High Intensity Interval Training and Time-Restricted Feeding Strategies Against Obesity-Induced Memory Decline
Poster Presentation
Paper ID : 1381-SSRC
Authors
1محقق پسادکتری، گروه فیزیولوژی ورزشی، دانشکده علوم ورزشی، دانشگاه الزهرا، تهران، ایران.
2گروه فیزیولوژی ورزش، دانشکده علوم ورزشی، دانشگاه الزهرا، تهران، ایران
Abstract
Introduction: Consuming a high-fat diet (HFD) for an extended period raises significant health concerns due to its association with various issues, lower quality of life, and increased mortality rates. Obesity-induced by HFD results in problems such as high lipidaemia and high blood pressure. Obesity also elevates the risk of neurological and cognitive problems, emphasizing mental health concerns. Adopting lifestyle changes, including exercise training and reduced calorie intake, is crucial in addressing obesity-related issues. Despite evidence linking obesity to memory decline, it remains unclear if exercise and reduced calorie intake genuinely enhance memory in obese individuals. Therefore, this study aims to examine how high-intensity interval training (HIIT) and time-restricted feeding (TR) affect the cognitive performance of adult male mice.
Method: This study involved thirty male C57BL/6 mice, (aged five weeks and weighing 15 ± 2 g). After a familiarization period, the mice were divided into five groups: standard diet (STD), HIIT, HIIT + TR, TR, and HFD. Following fourteen weeks of HFD feeding, except for the STD group, groups HIIT and HIIT+TR performed HIIT (5 times/week), and groups HIIT+TR and TR adhered to time-restricted feeding (8 hours of access to food and 16 hours of limitation on food) for eight weeks. The Y-maze test assessed working memory behaviour at the protocol's conclusion. Statistical analysis involved one-way ANOVA and Bonferroni post hoc testing for group differences.
Result: Our findings indicate that HFD significantly lowers working memory compared to the STD group. However, HIIT, TR, and a combination of both can enhance working memory compared to HFD. We didn't observe significant differences between the HIIT, TR, and HIIT+TR groups (p < 0.05).
Conclusion: While HIIT, TR, and HIIT+TR show potential in improving cognitive impairment caused by HFD feeding, their efficacy does not surpass that observed with STD feeding.
Method: This study involved thirty male C57BL/6 mice, (aged five weeks and weighing 15 ± 2 g). After a familiarization period, the mice were divided into five groups: standard diet (STD), HIIT, HIIT + TR, TR, and HFD. Following fourteen weeks of HFD feeding, except for the STD group, groups HIIT and HIIT+TR performed HIIT (5 times/week), and groups HIIT+TR and TR adhered to time-restricted feeding (8 hours of access to food and 16 hours of limitation on food) for eight weeks. The Y-maze test assessed working memory behaviour at the protocol's conclusion. Statistical analysis involved one-way ANOVA and Bonferroni post hoc testing for group differences.
Result: Our findings indicate that HFD significantly lowers working memory compared to the STD group. However, HIIT, TR, and a combination of both can enhance working memory compared to HFD. We didn't observe significant differences between the HIIT, TR, and HIIT+TR groups (p < 0.05).
Conclusion: While HIIT, TR, and HIIT+TR show potential in improving cognitive impairment caused by HFD feeding, their efficacy does not surpass that observed with STD feeding.
Keywords