The Effect of Pre-Pregnancy Aerobic Exercise and Physical Activity During Pregnancy on Myostatin and Follistatin myokin gene expression in Gastrocnemius muscle tissue Female Rats after childbearing.
Oral Presentation
Paper ID : 1400-SSRC
Authors
دانشگاه زنجان، دانشکده علوم انسانی
Abstract
Physical activities induce changes in gene expression that affect metabolic and structural initiation adaptations in skeletal muscle that can release some myokines. On the other hand, physical activity can affect the amount of myokines. Objective: The effect of aerobic training of parent rats before pregnancy and physical activity of the mother rat during pregnancy was on the expression of Myostatin and Follistatin genes in the Gastrocnemius muscle tissue Female Rats after childbearing. Methodology: 96 female (N=48) and male (N=48) rats (age=8w) based on weight and randomly divided into four groups (two groups of male rats (N=24) and two groups of female rats (N=24) ) were divided. Each of the male and female groups was a training group and a control group. After familiarization and division, the training groups did increasing aerobic training (6 weeks and 5 days a week, speed 10-18 meters per minute) on the treadmill. After finishing the training, the female rats were placed in separate cages next to the male rats of the same group for mating. After observing the first vaginal plaque, the pregnant rats were separated from the male rats and again divided into two training and non-training groups. The group of pregnant rats engaged in physical activity (about 21 days, 35-45% of VO2max, 5 days a week). Three weeks After the children were born, they were unconscious and their muscle tissue was removed. Results: The results showed that previous aerobic training and physical activity during pregnancy had no significant effect on the amount of myostatin and follistatin. Conclusion: Aerobic exercise before pregnancy and physical activity during pregnancy did not have a significant effect on the gene expression of myokines myostatin and follistatin in the Gastrocnemius muscle tissue of twin female rats after giving birth. Therefore, it seems that these exercises do not provide a sufficient effect mechanism to activate the most important myogenic and myostatic factors in pregnant women.
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