The effect of aerobic training of parent rats before pregnancy and physical activity of mother rats during pregnancy on the expression of AMPK, PGC-1α and TFAM genes in the heart tissue of their male offspring.
Oral Presentation
Paper ID : 1406-SSRC
Authors
1دانشگاه زنجان دانشکده علوم انسانی
2استادیار گروه علوم ورزشی ،دانشگده علوم انسانی،دانشگاه زنجان،دانشگاه زنجان،ایران
3استادیار گروه علوم ورزشی،دانشکده علوم انسانی،دانشگاه زنجان،زنجان،ایران
Abstract
Background: Exercise can modify genes through epigenetics and cause transmission to the next generations. Objective: The effect of aerobic training of parent rats before pregnancy and physical activity of the mother rat during pregnancy was on the expression of AMPK, PGC-1α and TFAM genes in the heart tissue of their male offspring. Methodology: 96 female (N=48) and male (N=48) rats (age=8w) based on weight and randomly divided into four groups (two groups of male rats (N=24) and two groups of female rats (N=24) ) were divided. Each of the male and female groups was a training group and a control group. After familiarization and division, the training groups did increasing aerobic training (6 weeks and 5 days a week, speed 10-18 meters per minute) on the treadmill. After finishing the training, the female rats were placed in separate cages next to the male rats of the same group for mating. After observing the first vaginal plaque, the pregnant rats were separated from the male rats and again divided into two training and non-training groups. The group of pregnant rats engaged in physical activity (about 21 days, 35-45% of VO2max, 5 days a week). After the children were born at the age of 8 weeks, they were unconscious and their heart tissue was removed. Results: The expression of AMPK and PGC-1α gene in aerobic exercise groups of parents before pregnancy was significantly better gnancy respectively and the expression of AMPK and TAFM gene in the father's aerobic exercise group before pregnancy and father and mother's aerobic exercise before pregnancy and mother's physical activity during pregnancy were significantly higher than the control group. Conclusion: It seems that exercise can be effective in preventing congenital cardiovascular diseases. Keywords: "aerobic exercise", "physical activity", "pregnancy ' Mitochondrial bioenzyme"
Keywords