Eight weeks of high-intensity interval swimming training improve cognitive memory in rats with non-alcoholic steatohepatitis.
Poster Presentation
Paper ID : 1434-SSRC
Authors
1دانشگاه تهران
2استاد، گروه فیزیولوژی فعالیت ورزشی، دانشکده علوم ورزشی و تندرستی، دانشگاه تهران، تهران، ایران
3عضو هیات علمی بخش علوم ورزشی دانشگاه شیراز
Abstract
Aim: Disturbance in beta-oxidation of fatty acids and increase in triglyceride accumulation in liver cells causes non-alcoholic steatohepatitis, which can disrupt hippocampus-dependent cognitive memory. Sports activity can improve cognitive memory by reducing inflammatory factors. The current study investigated the effect of eight weeks of high-intensity interval swimming training on cognitive memory and the expression of PGC-1α and IL-6 proteins in the brain hippocampus in rats with non-alcoholic steatohepatitis. method: In the present study, 40 male Sprague-Dawley rats were divided into two groups: healthy (n=20) and high-fat diet (HFD) (n=20). The HFD group received a high-fat diet for eight weeks to develop the disease. After proving the disease, the rats were divided into four groups: control-healthy (n=9), training-healthy (n=9), control-disease (n=9) and training-disease (n=9). After dividing the groups, all the rats in the training groups 48 hours after familiarization with the animal pool, first warmed up for 5 minutes and then the main exercise of HIIT (High Intensity Interval Training) swimming, including 20 times of 30 seconds of swimming with 30 seconds of rest in between. It was performed for eight weeks (three days a week). At the end, cognitive memory was evaluated by the Water Morris Maze behavioral test and PGC-1α and IL-6 proteins in the hippocampus of the brain were measured by ELISA method, One-way analysis of variance with Bonferroni post hoc test was used for data analysis (p<0.05) and all statistical methods were performed using spss version 26 software. Result: Based on the results of one-way variance analysis, it can be said that a significant difference between the means in the variable of time to reach the platform (T) in the Water Morris maze test was observed in the present study and the highest and lowest amount of PGC-1α protein was observed in training-healthy and control-disease groups, respectively. Also, in the IL-6 variable, the highest and lowest levels were observed in the control-disease and training-healthy groups, respectively. Conclusion: high intensity interval swimming training in NASH can improve memory function and increase PGC-1α and decrease IL-6 in the brain hippocampus.
Keywords