The effect of Prepregnancy aerobic training and physical activity during pregnancy on oxidative stress of uterine and ovarian tissues of maternal rats after childbirth
Oral Presentation
Paper ID : 1484-SSRC
Authors
1ندارد
2عضو هیئت علمی دانشگاه زنجان
Abstract
Research background and purpose: Pregnancy can lead to complications in the body and disorders in the tissue of the uterus and ovaries due to a decrease in the activity of antioxidants, and increasing oxidative stress. The aim of this study is the effect of aerobic training before pregnancy and physical activity during pregnancy on the level of glutathione peroxidase, superoxide dismutase, total antioxidant capacity and malondialdehyde of uterine and ovarian tissues of maternal rats after delivery.
Materials & Method: 48 female rats (age = 8 weeks) were randomly divided into two groups of 24 female rats. Each of the female groups was a training group and a control group. the training groups did increasing aerobic training (6 weeks and 5 days a week, speed 10-18 meters per minute) on the treadmill. After finishing the training, the female rats were placed in separate cages next to the male rats of the same group for mating. After observing the first vaginal plaque, the pregnant rats were separated and again divided into two training and non-training groups. The group of pregnant rats engaged in physical activity (about 21 days, 35-45% of VO2max, 5 days a week). After termination of pregnancy and delivery of female rats and also three weeks after giving birth, uterine and ovaries tissues of rats were separated and analyzed in the laboratory.
Results: there were significant changes in the levels of TAC, GPX and SOD in the ovarian tissue of maternal rats in the aerobic training before pregnancy group and also the TAC levels of aerobic training before pregnancy and physical activity during pregnancy group were significantly higher than the control group. In uterine tissue, significant changes in the level of GPX enzyme were observed in the pre-pregnancy aerobic training group.
Conclusion: it seems that long-term aerobic exercise has more effects on the adaptation of the oxidative stress system, so that it has led to the improvement of the antioxidant function in the tissue of the uterus and ovary, which can ultimately affect the health and function of these tissues.
Materials & Method: 48 female rats (age = 8 weeks) were randomly divided into two groups of 24 female rats. Each of the female groups was a training group and a control group. the training groups did increasing aerobic training (6 weeks and 5 days a week, speed 10-18 meters per minute) on the treadmill. After finishing the training, the female rats were placed in separate cages next to the male rats of the same group for mating. After observing the first vaginal plaque, the pregnant rats were separated and again divided into two training and non-training groups. The group of pregnant rats engaged in physical activity (about 21 days, 35-45% of VO2max, 5 days a week). After termination of pregnancy and delivery of female rats and also three weeks after giving birth, uterine and ovaries tissues of rats were separated and analyzed in the laboratory.
Results: there were significant changes in the levels of TAC, GPX and SOD in the ovarian tissue of maternal rats in the aerobic training before pregnancy group and also the TAC levels of aerobic training before pregnancy and physical activity during pregnancy group were significantly higher than the control group. In uterine tissue, significant changes in the level of GPX enzyme were observed in the pre-pregnancy aerobic training group.
Conclusion: it seems that long-term aerobic exercise has more effects on the adaptation of the oxidative stress system, so that it has led to the improvement of the antioxidant function in the tissue of the uterus and ovary, which can ultimately affect the health and function of these tissues.
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