The Effect of Four Weeks of Aerobic Swimming on SNAP25 Synaptosomal Protein in Experimental Autoimmune Encephalomyelitis (EAE) Female Mice
Oral Presentation
Paper ID : 1583-SSRC
Authors
1دانشگاه تربیت مدرس
2Department of Sport Science Faculty of Humanities Tarbiat Modares University Tehran, IRAN
3Dept.exercise science, faculty of humanities, tarbiat modares university
4Department of Exercise Physiology, Faculty of Health and Sports Sciences, University of Tehran
Abstract
Title (s): Multiple sclerosis (MS) is an autoimmune inflammatory disease of the central nervous system that affects cognitive function during development. About three million people in the world have reported MS, with a ratio of 3 to 2 between women and men. Also, about 45-70% of patients suffer from cognitive disorders. A significant change in the central nervous system of these patients is the synaptic dysfunction that occurs before the demyelination of axons and neural pathways. Physical activity is promising in the prevention and treatment of such conditions. This study was conducted with the aim of investigating the changes caused by swimming exercise on the amount of presynaptic membrane protein SNAP25 in the brain tissue of female rats involved in cognitive and inflammatory disorders in the experimental encephalomyelitis (EAE) animal model
Materials and Methods: 21 C57BL/6 mice were used in three groups: control (7 samples), experimental autoimmune encephalomyelitis without exercise (7 samples), and with 4 weeks of aerobic swimming exercise (7 samples). Clinical scores were recorded daily, and snap25 protein levels were measured after 4 weeks of exercise.
Findings: EAE induction increased snap25 levels compared to the healthy control group, but swimming exercise managed to reduce it by 27% (P-value=0.0003, F=42.92, EF= 0.85 ) . Meanwhile, clinical scores also improved in exercised mice with the disease.
Conclusion: Regular daily exercise regulates snap25 expression in brain tissue, modulating neural mediators and trophic factors in the synaptic region under inflammatory conditions, potentially improving cognitive disorder symptoms.
Swimming can be effective in preventing cognitive impairment in this disease by improving clinical scores and cognitive performance.
Materials and Methods: 21 C57BL/6 mice were used in three groups: control (7 samples), experimental autoimmune encephalomyelitis without exercise (7 samples), and with 4 weeks of aerobic swimming exercise (7 samples). Clinical scores were recorded daily, and snap25 protein levels were measured after 4 weeks of exercise.
Findings: EAE induction increased snap25 levels compared to the healthy control group, but swimming exercise managed to reduce it by 27% (P-value=0.0003, F=42.92, EF= 0.85 ) . Meanwhile, clinical scores also improved in exercised mice with the disease.
Conclusion: Regular daily exercise regulates snap25 expression in brain tissue, modulating neural mediators and trophic factors in the synaptic region under inflammatory conditions, potentially improving cognitive disorder symptoms.
Swimming can be effective in preventing cognitive impairment in this disease by improving clinical scores and cognitive performance.
Keywords