EFFECT ENDURANCE TRAINING ON THE EXPRESSION OF SOME MITOCHONDRIALGENES IN THE HIPPOCAMPUS OF DIABETIC MALE RATS
Poster Presentation
Paper ID : 1613-SSRC
Authors
1دانشگاه محقق اردبیلی
2دانشگاه تبریز
3دانشگاه پیام نور البرز
Abstract
Background & Aims: Diabetes is a chronic non-communicable disease , Hyperglycemia causes disorders of cardiovascular system, kidneys, retina, lens of the eyes, skin, and central and peripheral nervous system. Common type of exercises are endurance training that improve glycemic control, lipid profile and blood glucose. therefore, the aim of study was,the effect of endurance training on the expression of some mitochondrial genes in the hippocampus of diabetic male rats.
Materials & Methods: The present study was an experimental study with a post-test design with a
control group that was performed by laboratory method. In the present study, 21 Wistar rats were divided into 3 groups (7 in each) including: healthy control, control diabetic, exercise diabetic.
The protocol used in the present study was 6 weeks’ moderate intensity endurance training
(55-50% of maximum oxygen consumption). Hippocampal tissue was taken surgically 24 hours after
the last training session to evaluate the expression of PGC-1α and Atf2 genes. One-way analysis of
variance with Tukey post-hoc test (with a significance level of P <0.05) was used to examine the data.
Results: Results showed that the expression of PGC-1α and Atf2 genes in diabetic control decreased significantly compared to the helthy control(P <0.05) and The diabetic exercise group had a
significant increase compared to the diabetes control group for both of the genes (P <0.05).
Conclusion: It seems that 6 weeks’ endurance training has a positive effect on mitochondrial PGC-1α and Atf2 gene expression, and increases them in the diabetic patients.
Keywords: Atf2, Endurance Training, Mitochondria, PGC-1α
Materials & Methods: The present study was an experimental study with a post-test design with a
control group that was performed by laboratory method. In the present study, 21 Wistar rats were divided into 3 groups (7 in each) including: healthy control, control diabetic, exercise diabetic.
The protocol used in the present study was 6 weeks’ moderate intensity endurance training
(55-50% of maximum oxygen consumption). Hippocampal tissue was taken surgically 24 hours after
the last training session to evaluate the expression of PGC-1α and Atf2 genes. One-way analysis of
variance with Tukey post-hoc test (with a significance level of P <0.05) was used to examine the data.
Results: Results showed that the expression of PGC-1α and Atf2 genes in diabetic control decreased significantly compared to the helthy control(P <0.05) and The diabetic exercise group had a
significant increase compared to the diabetes control group for both of the genes (P <0.05).
Conclusion: It seems that 6 weeks’ endurance training has a positive effect on mitochondrial PGC-1α and Atf2 gene expression, and increases them in the diabetic patients.
Keywords: Atf2, Endurance Training, Mitochondria, PGC-1α
Keywords