The effect of aerobic exercise on serum glucose and insulin levels and FGF23 gene expression in the heart of diabetic rats
Poster Presentation
Paper ID : 1622-SSRC
Authors
1Professor of Exercise Physiology, Department of Physical Education and Sport Sciences, Faculty of Humanities, Tarbiat Modares University, Tehran, Iran.
2Ph.D. student of Exercise Physiology, Department of Physical Education and Sport Sciences, Faculty of Humanities, Tarbiat Modares University, Tehran, Iran
Abstract
Background and objective: Diabetic patients are highly susceptible to cardiovascular involvement. Cardiovascular complications are one of the most common and fatal clinical consequences of type 2 diabetes. Therefore, the aim of the present study was to investigate the effect of aerobic exercise on serum glucose and insulin levels and FGF23 gene expression in the heart of diabetic rats.
Materials and methods: In this experimental study, the samples included 48 male Wistar rats, which were divided into 4 groups: control group (C), diabetes- training group (DT), diabetes- training group (DT) and training group (T). Diabetes was induced by streptozotocin injection. 5 sessions per week of aerobic exercise were performed for 6 weeks. Analyzing the expression of FGF23 gene in heart tissue was done using Real-time PCR laboratory method and Serum glucose and insulin were measured with a specialized kit. one-way variance test were used to analyze the data.
Resalt: Based on the results, the amount of serum glucose (p=0.013) and insulin (p=0.021) levels showed a significant decrease after six weeks of aerobic training. Also, there was significant difference between the DT and DC groups in the expression of FGF23 gene (relative expression) (p=0.031).
Conclusion: It seems that six weeks of moderate intensity aerobic training increases glucose and insulin levels and FGF23 gene expression. Diabetes increases serum glucose and insulin levels and FGF23 gene expression in the heart. The results suggested that aerobic exercise has a positive effect on the serum levels of glucose and insulin and expression of FGF23 gene, and it appears to be somewhat protective of heart function.
Materials and methods: In this experimental study, the samples included 48 male Wistar rats, which were divided into 4 groups: control group (C), diabetes- training group (DT), diabetes- training group (DT) and training group (T). Diabetes was induced by streptozotocin injection. 5 sessions per week of aerobic exercise were performed for 6 weeks. Analyzing the expression of FGF23 gene in heart tissue was done using Real-time PCR laboratory method and Serum glucose and insulin were measured with a specialized kit. one-way variance test were used to analyze the data.
Resalt: Based on the results, the amount of serum glucose (p=0.013) and insulin (p=0.021) levels showed a significant decrease after six weeks of aerobic training. Also, there was significant difference between the DT and DC groups in the expression of FGF23 gene (relative expression) (p=0.031).
Conclusion: It seems that six weeks of moderate intensity aerobic training increases glucose and insulin levels and FGF23 gene expression. Diabetes increases serum glucose and insulin levels and FGF23 gene expression in the heart. The results suggested that aerobic exercise has a positive effect on the serum levels of glucose and insulin and expression of FGF23 gene, and it appears to be somewhat protective of heart function.
Keywords