The effect of endurance exercise on PGC-1α / FNDC5 signaling pathway in hippocampus of Wistar rats
Poster Presentation
Paper ID : 1631-SSRC
Authors
1دانشجو
2هیات علمی
Abstract
Exercise activities especially endurance exercise have beneficial effects on the brain health
and cognitive function. Neurotrophins are one of the most important factors that can be affected by exercise on memory, learning and biochemical factors. The aim of this study is analysis the effect of endurance training with moderate intensity in 12 weeks on the PGC-1α / FNDC5 signaling pathway in the hippocampus of the male wistar rats. 16 male wistar rats were randomly selected in 2 groups
and directly controlled and tested. The wistar rats of the examination group participated in the
endurance training for 12 weeks. The rats exercised for 5 sessions per week and in 12 weeks.
After the first week, the started activity increased from 10 meters per minute to 20 meters per
minute and the time reached from 15 minutes to 45 minutes and after the second week, the
time and speed were fixed. The tissue samples were taken 48 hours after the last training
session. The collected statistical data were analyzed by statistical software 21SPSS. Then, the
independent t-test was used to analysis the intergroup changes. All statistical test was
considered according to the significance level at α = 0/05. The results showed that there is a
significant increase in FNDC5 and PGC-1α gene expression in the examination group
comparison with control group (P≤0.05). It seems, the regular and continuous endurance
exercise can increase the PGC-1α and then FNDC5 gene expression which led to improve the
process of preservation, maintenance, nutrition and the growth of nerve cells.
and cognitive function. Neurotrophins are one of the most important factors that can be affected by exercise on memory, learning and biochemical factors. The aim of this study is analysis the effect of endurance training with moderate intensity in 12 weeks on the PGC-1α / FNDC5 signaling pathway in the hippocampus of the male wistar rats. 16 male wistar rats were randomly selected in 2 groups
and directly controlled and tested. The wistar rats of the examination group participated in the
endurance training for 12 weeks. The rats exercised for 5 sessions per week and in 12 weeks.
After the first week, the started activity increased from 10 meters per minute to 20 meters per
minute and the time reached from 15 minutes to 45 minutes and after the second week, the
time and speed were fixed. The tissue samples were taken 48 hours after the last training
session. The collected statistical data were analyzed by statistical software 21SPSS. Then, the
independent t-test was used to analysis the intergroup changes. All statistical test was
considered according to the significance level at α = 0/05. The results showed that there is a
significant increase in FNDC5 and PGC-1α gene expression in the examination group
comparison with control group (P≤0.05). It seems, the regular and continuous endurance
exercise can increase the PGC-1α and then FNDC5 gene expression which led to improve the
process of preservation, maintenance, nutrition and the growth of nerve cells.
Keywords