Oral Presentation

Paper ID : 1714-SSRC

¹دانشگاه گیلان

²2. استاد، فیزیولوژی ورزشی، دانشکده تربیت بدنی و علوم ورزشی، دانشگاه گیلان، رشت، ایران.

Background and Aim: Non-alcoholic fatty liver disease (NAFLD) prevalence is increasing in different societies. Exercise and changing oxygen levels have been studied as potential treatments for NAFLD since there is currently no approved drug for this condition. However, There's no agreement on the ideal volume and intensity of these interventions for optimal results. This study investigated the effect of different exercise intensities in hypoxia and normoxia conditions on liver fat content and endurance performance of male rats fed a high-fat diet. Materials and Methods: 48 male Wistar rats (5 weeks) were randomly divided into groups of normal diet (ND), high-fat diet (HFD), high-fat diet and moderate-intensity training (HFD-MICT), high-fat diet and hypoxia moderate-intensity training. (HFD-HMICT), high-fat diet and high intensity interval training (HFD-HIIT), high-fat diet and hypoxia high intensity interval training (HFD-HHIIT). After determining the maximum aerobic velocity, the exercises were performed for 12 weeks and three sessions per week in normoxia (altitude ̴of 50 m) and hypoxia-hypobaric (altitude ̴ 3000 m). At the end, tissue and blood samples were collected. The data were analyzed with ANOVA statistical test. Results: The results showed that weight, liver fat content, and leukocyte number were higher in the HFD group, and endurance performance was lower than in all groups (p<0.05). The lowest rate of weight gain and fat content and the highest endurance performance were in the high intensity interval training groups (p<0.05). There was no significant difference between HFD-HHIIT and HFD-HIIT groups. Endurance performance in MICT groups was lower than in HIIT groups. The increase in aerobic performance under hypoxic conditions was independent of RBC and HGB changes. Conclusion: MICT in hypoxia did not bring additional benefits in reducing liver fat content compared to normoxia. Although the decrease in fat content in the HHIIT group was not significant compared to the HIIT group, these results may be clinically promising. The increase in endurance performance in the HFD-HHIIT group is independent of changes in blood factors related to oxygen transport capacity; probably, the intervention of this research does not induce sufficient stimulation for blood changes due to short-term exposure to hypoxia.

non-alcoholic fatty liver disease; hypoxia; Exercise; Diet; High-Fat; Blood cells