Effects of combined exercise training on physical and physiological indices in MS patients
Poster Presentation
Paper ID : 1715-SSRC
Authors
1دانشجوی دکتری تربیت بدنی گرایش فیزیولوژی ورزش، دانشگاه آزاد واحد بجنورد، بجنورد، ایران
2استادیار گروه تربیت بدنی، دانشگاه آزاد اسلامی واحد بجنورد، بجنورد، ایران
3استادیار گروه تربیت بدنی، دانشگاه آزاد واحد بجنورد، بجنورد، ایران
Abstract
Background: Multiple sclerosis (MS) is an early-onset immune-mediated, neurodegenerative disease of the central nervous system that affects the brain and spinal cord and causes disturbances in the conduction of nerve and electrical currents. It is assumed that people with MS who participate in physical exercise programs improve their physical fitness. However, previous evidence suggests unclear results.
Aim: This study aimed to investigate the effect of eight weeks of combined training on the gene expression of neuregulin-1, Plasma levels of NT-3 and NT-4, and balance in women with MS.
Materials and Methods. Thirty women with MS mean age 47.7±4.79 years and weight 69.70±5.5 kg living in Mashhad were randomly divided into experimental (15 people) and control (15 people). The experimental group performed combined training including resistance training with an intensity of 65 to 85% of one maximum repetition and aerobic training with 60 to 70% of maximum heart rate for eight weeks, three days a week, and 45 minutes in each session while the control group did not participate in any sports program during this period. Blood samples were taken from the brachial vein before and 48 hours after exercise in a fasting state. Neuroglin-1 gene expression was determined using the Real-Time PCR method. The plasma levels of NT-3 and NT-4 were measured using the Zell Bio Elisa kit made in Germany. The balance index was measured by BDI and TUG tests. Data were analyzed using independent t-test and paired t-test at the significant level of p≤0.05.
Results: Combined training significantly increased neuregulin-1 gene expression (p=0.001), NT-3 (P= 0.001), NT-4 (P= 0.001), static balance (p=0.001), and dynamic balance (p=0.001) in MS people.
Conclusion: The results show that combined training could be a non-pharmacological exercise-based interventional strategy and suggest a neuroprotective effect of combined training in this population and encourage us to investigate further the beneficial impact of physical exercise and to emphasize the importance of lifestyle in MS.
Aim: This study aimed to investigate the effect of eight weeks of combined training on the gene expression of neuregulin-1, Plasma levels of NT-3 and NT-4, and balance in women with MS.
Materials and Methods. Thirty women with MS mean age 47.7±4.79 years and weight 69.70±5.5 kg living in Mashhad were randomly divided into experimental (15 people) and control (15 people). The experimental group performed combined training including resistance training with an intensity of 65 to 85% of one maximum repetition and aerobic training with 60 to 70% of maximum heart rate for eight weeks, three days a week, and 45 minutes in each session while the control group did not participate in any sports program during this period. Blood samples were taken from the brachial vein before and 48 hours after exercise in a fasting state. Neuroglin-1 gene expression was determined using the Real-Time PCR method. The plasma levels of NT-3 and NT-4 were measured using the Zell Bio Elisa kit made in Germany. The balance index was measured by BDI and TUG tests. Data were analyzed using independent t-test and paired t-test at the significant level of p≤0.05.
Results: Combined training significantly increased neuregulin-1 gene expression (p=0.001), NT-3 (P= 0.001), NT-4 (P= 0.001), static balance (p=0.001), and dynamic balance (p=0.001) in MS people.
Conclusion: The results show that combined training could be a non-pharmacological exercise-based interventional strategy and suggest a neuroprotective effect of combined training in this population and encourage us to investigate further the beneficial impact of physical exercise and to emphasize the importance of lifestyle in MS.
Keywords