Investigating Interleukin 17, Quality of Life and Mental Fatigue in multiple sclerosis with an Innovative approach of combining aerobic and cognitive activity: Effect of Brythonic Training
Poster Presentation
Paper ID : 1716-SSRC
Authors
1دانشجوی دکترا فیزیولوژی ورزشی، دانشکده علوم ورزشی و تندرستی، دانشگاه شهید بهشتی، تهران، ایران
2گروه فیزیولوژی ورزشی، دانشکده علوم ورزشی و تندرستی، دانشگاه شهید بهشتی، تهران، ایران
3گروه فیزیولوژی ورزشی، دانشکده تربیت بدنی و علوم ورزشی، دانشگاه خوارزمی، تهران، ایران
4گروه مغز و اعصاب، دانشگاه علوم پزشکی شهید بهشتی، بیمارستان امام حسین، تهران، ایران
Abstract
Objectives: Combined physical-cognitive training is one of the effective interventions for patients with Multiple Sclerosis (MS), which may affect cognitive disorders. The present study aimed to investigate changes in patients with MS by performing combined aerobic-cognitive training (Brythonic) and conventional aerobic training (Aerotonic).
Methods: Thirty patients (22 women and 8 men) with Relapsing-Remitting and Expanded Disability Status Scale (EDSS) less than four (Mean ± SD; age, 36.66±9.36 years; height,164.5±6.3 cm; weight, 65.43±9.80 kg; body mass index, 24.02±3.02 kg/m2) were randomly divided into 3 equal groups of Brythonic training, Aerotonic training, and control. Subjects in Brythonic and Aerotonic groups performed 10 weeks of home-based online training, two sessions per week. The activity of the Brythonic group was to perform motivational words with aerobic movements in each session. During ten weeks, these words formed a complete sentence with a positive meaning. In the Aerotonic group, the same aerobic movements as the Brythonic group were performed, with the difference that there was no cognitive load. The control group did not have any training activities. In the pre-test and also after ten weeks of online training at home, the values of Interleukin 17 (IL17), Multiple Sclerosis Quality of Life-54 Questionnaires (MSQOL-54), Modified Fatigue Impact Scale (MFIS) were evaluated. The significance level was considered P≥ 0.05 for statistical analysis in all results.
Results: The Interleukin 17 variable significantly decreased in the Brythonic group (P>0.0001). MSQOL-54 variable substantially differed in physical health items in the Brythonic group compared to the control. In MFIS, a significant difference was observed between the training groups with the control. Notably, in all the variables, the Brythonic group significantly improved before and after ten weeks of training in the results within the group. The significance of this can be observed in the control group, indicating a contrast to the Brythonic group and an escalation in symptoms.
Conclusion: This study concluded that although aerobic activity even with moderate intensity has positive effects on MS fatigue, adding cognitive load to the same intensity of aerobic activity can improve other aspects of the disease, especially the inflammatory factor.
Methods: Thirty patients (22 women and 8 men) with Relapsing-Remitting and Expanded Disability Status Scale (EDSS) less than four (Mean ± SD; age, 36.66±9.36 years; height,164.5±6.3 cm; weight, 65.43±9.80 kg; body mass index, 24.02±3.02 kg/m2) were randomly divided into 3 equal groups of Brythonic training, Aerotonic training, and control. Subjects in Brythonic and Aerotonic groups performed 10 weeks of home-based online training, two sessions per week. The activity of the Brythonic group was to perform motivational words with aerobic movements in each session. During ten weeks, these words formed a complete sentence with a positive meaning. In the Aerotonic group, the same aerobic movements as the Brythonic group were performed, with the difference that there was no cognitive load. The control group did not have any training activities. In the pre-test and also after ten weeks of online training at home, the values of Interleukin 17 (IL17), Multiple Sclerosis Quality of Life-54 Questionnaires (MSQOL-54), Modified Fatigue Impact Scale (MFIS) were evaluated. The significance level was considered P≥ 0.05 for statistical analysis in all results.
Results: The Interleukin 17 variable significantly decreased in the Brythonic group (P>0.0001). MSQOL-54 variable substantially differed in physical health items in the Brythonic group compared to the control. In MFIS, a significant difference was observed between the training groups with the control. Notably, in all the variables, the Brythonic group significantly improved before and after ten weeks of training in the results within the group. The significance of this can be observed in the control group, indicating a contrast to the Brythonic group and an escalation in symptoms.
Conclusion: This study concluded that although aerobic activity even with moderate intensity has positive effects on MS fatigue, adding cognitive load to the same intensity of aerobic activity can improve other aspects of the disease, especially the inflammatory factor.
Keywords