Poster Presentation

Paper ID : 1747-SSRC

عضو هیات علمی دانشگاه

MicroRNA-126 (miR-126) is a non-coding, post-transcriptional regulator of gene expression. Dysregulation of miR-126 has been associated with the development of various diseases, including hypertension. Various targets of miR-126 have been proposed for cardiovascular fitness, such as sprouty-related, EVH1 domain-containing protein 1 (SPRED1), phosphoinositide-3-kinase regulatory subunit 2 (PIK3R2), vascular cell adhesion molecule 1 (VCAM1), tumor necrosis factor receptor-associated factor 7 (TRAF7) and high-mobility group box 1 (HMGB1). These proteins are engaged in various cellular processes such as inflammation, angiogenesis, and apoptosis, which are vital for cardiovascular health. Also, miR-126 is known to play a significant role in cardiovascular health, and its levels in the myocardium and circulation are affected by exercise protocols. Furthermore, miR-126 is an angiogenetic regulator abundant in endothelial cells (ECs) and endothelial progenitor cells (EPCs). According to the few studies conducted until now, chronic aerobic exercise has been demonstrated to raise circulating and myocardial miR-126 levels in both diseased and healthy people. These results imply that miR-126 could be the essential molecule impacted by chronic aerobic exercise in a dose–response manner and might be involved in early protecting the cardiac function. The increase in miR-126 levels through aerobic exercise may influence these processes, thereby contributing to cardiovascular health. Tissue hypoxia caused by high-intensity exercise perchance be responsible for the increase of miR-126 expression. Hypoxia induces the expression of hypoxia-inducible factor -1α (HIF-1α) and its downstream Ets-1 which can regulate miR-126 in vascular ECs. Moreover, EPCs promoted from the bone marrow into the bloodstream may be another reason for circulating miR-126 increase. Studies have shown that acute or chronic moderate-and high-intensity aerobic exercise, are able to increase circulating miR-126 in healthy adults. Chronic aerobic exercise can effectively rescue the reduction of myocardial and circulating miR-126 and vascular endothelial growth factor (VEGF) in diabetic mice against diabetic vascular injury. Also, miR-126 suppresses cell adhesion molecule and proangiogenic after regulate exercise training. These findings suggest that aerobic exercise may have a significant impact on miR-126 levels. However, the exact mechanisms by which aerobic exercise influences miR-126 levels and its downstream effects are still not fully understood and require further research.

Hypertension; endothelial dysfunction; Exercise Training; microRNA