Poster Presentation

Paper ID : 1749-SSRC (R1)

عضو هیات علمی دانشگاه

Hypertension, commonly known as high blood pressure, is a major risk factor for cardiovascular diseases such as heart failure, stroke, and coronary heart disease. The management of hypertension often involves lifestyle changes, including diet and exercise, and medication. Genistein is a type of isoflavone, found in soybeans, a class of compounds that are structurally similar to estrogens. It has been shown potential in the treatment of hypertension. Its mechanism of action involves multiple pathways including: promote vasodilation, antioxidant activity, enhance endothelial function by production of nitric oxide, renin-angiotensin system modulation and reduce harmful hypoxia effects and inhibit vessel remodeling. Also, research suggests that genistein may have a promising effect on improving cardiac dysfunction, ischemia, and reperfusion of the heart, decreasing cardiac toxicity, modulating lipid profile, restored ACE, PKC-βII and eNOS expression, and preserved renal ultrastructural integrity. These findings suggest that genistein has effects on eNOS activity in renal cells, leading to eNOS activation and NO synthesis. These effects could have been mediated by activation of PKC-βII. Regular physical activity is widely recognized as an effective non-pharmacological intervention for hypertension. Exercise has been shown to reduce blood pressure in hypertensive patients, with aerobic exercise, dynamic resistance training, and isometric exercise all demonstrating beneficial effects. The greatest reductions in blood pressure have been observed with isometric exercise. The combination of genistein supplementation and exercise could potentially offer a synergistic effect in the management of hypertension. Both genistein and exercise have been shown to increase levels of brain-derived neurotrophic factor (BDNF), which could contribute to their combined neuroprotective effect. While more research is needed to fully understand the mechanisms underlying the beneficial effects of genistein and exercise on hypertension, current evidence suggests that they could be effective strategies for managing this condition.

Exercise; Hypertension; genistein; Supplementation