Comparison of the effect of aerobic continues - versus high-intensity interval training on protein (ikkb) and insulin resistance ratio in the liver of diabetic rat with high-fat diet
Poster Presentation
Paper ID : 1808-SSRC
Authors
1Assistant professor, Islamic azad university, Firouzkouh branch,Tehran, Iran
2lecturer of Amir Kabir Farhangian University Alborz
3Assistant Professor of Sport Physiology, Department of Exercise Physiology, Faculty of Sport Sciences, Alzahra University.
Abstract
Background: Currently, the incidence of chronic metabolic diseases, especially obesity and type 2 diabetes, has been significant in developed and developing countries. Exercise and regular physical activity are recognized as an effective strategy for the prevention and treatment of type 2 diabetes. Long-term exercise has positive metabolic effects in obese or diabetic people.
Aim: The purpose of this study was to determine effect of the aerobic continuous - versus high-intensity, interval training on protein (Ikkb) and insulin resistance ratio in the liver of diabetic rat with high-fat diet.
Methodology: Twenty-four heads of male Wistar rats (weight 160-180 g) after 7 months of high-fructose-containing diet were divided into three groups of control, aerobic continuous and intermittent exercise. They practiced the protocol in five days a week for two months. Blood samples were collected 24 h after the last training session, and liver tissue was immediately extracted. Pearson correlation, one-way ANOVA and Tukey post hoc test were used to analyze the data.
Results and conclusions: Both exercise models reduced Ikkb gene expression in the liver of type 2 diabetic rats compared to the control group (P=0.005), but no significant differences were observed between the two exercise groups (P=0.877). There was a correlation between the expression of Ikkb gene and insulin resistance index such that Increase of Ikkb gene expression resulted in decrease of insulin resistance index (r=-0.642, p=0.003). The results of this research show that both HIIT and continuous aerobic training can be used to improve the studied parameters in diabetic subjects.
Aim: The purpose of this study was to determine effect of the aerobic continuous - versus high-intensity, interval training on protein (Ikkb) and insulin resistance ratio in the liver of diabetic rat with high-fat diet.
Methodology: Twenty-four heads of male Wistar rats (weight 160-180 g) after 7 months of high-fructose-containing diet were divided into three groups of control, aerobic continuous and intermittent exercise. They practiced the protocol in five days a week for two months. Blood samples were collected 24 h after the last training session, and liver tissue was immediately extracted. Pearson correlation, one-way ANOVA and Tukey post hoc test were used to analyze the data.
Results and conclusions: Both exercise models reduced Ikkb gene expression in the liver of type 2 diabetic rats compared to the control group (P=0.005), but no significant differences were observed between the two exercise groups (P=0.877). There was a correlation between the expression of Ikkb gene and insulin resistance index such that Increase of Ikkb gene expression resulted in decrease of insulin resistance index (r=-0.642, p=0.003). The results of this research show that both HIIT and continuous aerobic training can be used to improve the studied parameters in diabetic subjects.
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