Relationship between Monoamine Oxidase A Gene Variations with obesity and Physical Activity level
Poster Presentation
Paper ID : 1871-SSRC
Authors
1ندارم
2دانشگاه بجنورد
3دانشیار فیزیولوژی ورزشی، پژوهشکده علوم زیستی در ورزش، پژوهشگاه تربیت بدنی و علوم ورزشی، تهران، ایران
Abstract
PURPOSE: Obesity is known as the most common metabolic disease in the world and reducing energy consumption at rest can increase the risk of obesity. Monoamine oxidase A (MAO-‐A) is an enzyme that acts on monoamine neurotransmitters, such as dopamine, to cause inactivation. There are several polymorphisms in the promoter region of the MAO-A gene and these variations change transcriptional activity and the amount of MAO-A producted, leading to alterations in available dopamine levels. The purpose of this study was to examine the genetic basis (Monoamine oxidase A) underlying voluntary exercise.
METHODS: One hundred participants (age 18-65, Quchan city) completed the International Physical Activity Questionnaire (IPAQ) to assess their level of physical activity. DNA was collected and isolated from a cheek cell sample. The MAO-A genotype was identified using PCR with gene specific primers. MAO-A 3/3, 3/ 4 and 4/4 genotype individuals were used for analysis.
RESULTS: The research findings showed that there is no significant difference in body weight, body fat percentage and body mass index in people carrying different alleles of the MAO-A gene. In terms of physical activity, there is a significant difference between different alleles in MAOA genes. (P=0.0002, F=6.43). The level of physical activity in women carrying the MAO-A 4/4 allele is much lower than women carrying the other two alleles.
CONCLUSION: It is concluded that women with genetic variations leading to low acetylation of NHLH2 and high transcriptional 4/4 repeat VNTR in MAO‐A would be expected to show the highest levels of sedentary behavior.
METHODS: One hundred participants (age 18-65, Quchan city) completed the International Physical Activity Questionnaire (IPAQ) to assess their level of physical activity. DNA was collected and isolated from a cheek cell sample. The MAO-A genotype was identified using PCR with gene specific primers. MAO-A 3/3, 3/ 4 and 4/4 genotype individuals were used for analysis.
RESULTS: The research findings showed that there is no significant difference in body weight, body fat percentage and body mass index in people carrying different alleles of the MAO-A gene. In terms of physical activity, there is a significant difference between different alleles in MAOA genes. (P=0.0002, F=6.43). The level of physical activity in women carrying the MAO-A 4/4 allele is much lower than women carrying the other two alleles.
CONCLUSION: It is concluded that women with genetic variations leading to low acetylation of NHLH2 and high transcriptional 4/4 repeat VNTR in MAO‐A would be expected to show the highest levels of sedentary behavior.
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