Endurance training increases BDNF expression in the hippocampus of male Wistar rats

Poster Presentation
Paper ID : 1902-SSRC
2هیات علمی
Endurance exercise protects neurons, improves cognitive function, and improves learning and memory. Considering the important role of neurotrophins, especially BDNF, on neuroprotection, recent research 4 In this context, they have focused on investigating their therapeutic effects in preventing or reducing damage and neuronal atrophy. The aim of this study was to evaluate the effect of 12-weeks endurance training on FNDC5 / BDNF signaling pathway in the hippocampus of male Wistar rats. Endurance training on a treadmill was performed for 12 weeks at a moderate intensity for 5 days a week. The first and last 5 minutes of each session were dedicated to warming up and cooling down at a speed of 10 meters per minute, and the main running program in the first week was increased from a speed of 10 meters per minute to 20 meters per minute, and the time from 15 minutes to It reached 35 minutes and thus the total of each session became 45 minutes and continued in the same way until the end. For 12 weeks, the control group was placed on the treadmill for 15 minutes, 5 sessions a week, so that all the conditions, including the manipulation of the mice by the researcher, were the same for both groups, and the only difference between the control and experimental groups was in the training program. 48 hours after the last training session, hippocampal tissue samples were collected. Statistical data were analyzed using SPSS 21-statistical software. Independent t-test was used to examine the differences between groups. All statistical tests were considered with α = 0.05 according to the significance level. Endurance training increases the expression of the FNDC5 gene and its downstream BDNF gene, in the experimental group increased significantly compared to the control group (p≤0.05). This finding can be effective in reducing the symptoms and preventing neurodegenerative diseases.