The effect of aerobic training and nanomicelle curcumin supplementation on MDA and BAX and BCL2 activity levels on cardiotoxicity of mice infected with breast cancer in the phase of mani with doxorubicin.
Poster Presentation
Paper ID : 1969-SSRC
Authors
وزارت علوم
Abstract
Objective: Doxorubicin is a universal drug in the treatment of all types of cancers, which is limited due to its many side effects. Therefore, the present study has investigated the effect of aerobic exercise and the use of curcumin nanomicelles on the activity levels of BAX, BCL2 and MDA concentration in doxorubicin-induced cardiotoxicity in mice with breast cancer.
Materials and methods:In this research,which was of a fundamental type and controlled experimentally,24BalbC female rats were randomly divided into4groups:doxorubicin, doxorubicin patient and exercise,doxorubicin patient and nanocurcumin supplement and doxorubicin patient,exercise and supplement. Breast cancer induction was done with MC4-L2 cells.Doxorubicin 2mg/kg was injected subcutaneously 6times on days 28,21,14,7,1and35.The aerobic program consisted of 5sessions per week for 42days with an increase in the speed of the treadmill every two weeks including 14,16 and18 meters per minute and the use of nanocurcumin at a dose of100mg/k.The collected data were analyzed with SPSS24 and two-way analysis of variance with a significance level of 0.05 in the tests.
Findings: 6 weeks of aerobic training had no effect on BCL2 activity and MDA concentration, but it significantly decreased BAX activity. Taking nano curcumin supplement for 6 weeks decreased BAX activity and MDA concentration and significantly increased BCL2 activity. Conclusion 6 A week of aerobic training along with nanocurcumin supplementation had no effect on BAX activity and MDA concentration, but it caused an increase in BCL2 activity. (P≤0.05)
Conclusion:Aerobic exercise and the use of curcumin nano micelle supplement separately or at the same time can be effective in reducing the cardiac toxicity of doxorubicin in patients with breast cancer.
Materials and methods:In this research,which was of a fundamental type and controlled experimentally,24BalbC female rats were randomly divided into4groups:doxorubicin, doxorubicin patient and exercise,doxorubicin patient and nanocurcumin supplement and doxorubicin patient,exercise and supplement. Breast cancer induction was done with MC4-L2 cells.Doxorubicin 2mg/kg was injected subcutaneously 6times on days 28,21,14,7,1and35.The aerobic program consisted of 5sessions per week for 42days with an increase in the speed of the treadmill every two weeks including 14,16 and18 meters per minute and the use of nanocurcumin at a dose of100mg/k.The collected data were analyzed with SPSS24 and two-way analysis of variance with a significance level of 0.05 in the tests.
Findings: 6 weeks of aerobic training had no effect on BCL2 activity and MDA concentration, but it significantly decreased BAX activity. Taking nano curcumin supplement for 6 weeks decreased BAX activity and MDA concentration and significantly increased BCL2 activity. Conclusion 6 A week of aerobic training along with nanocurcumin supplementation had no effect on BAX activity and MDA concentration, but it caused an increase in BCL2 activity. (P≤0.05)
Conclusion:Aerobic exercise and the use of curcumin nano micelle supplement separately or at the same time can be effective in reducing the cardiac toxicity of doxorubicin in patients with breast cancer.
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