Aerobic training and Chlorella extracts mediated the intestinal microbiota in mice with colorectal cancer.
Poster Presentation
Paper ID : 1980-SSRC
Authors
1گروه فیزولوژی ورزشی، دانشکده علوم ورزشی، دانشگاه آزاد اسلامی، واحد اصفهان (خوراسگان)، اصفهان، ایران.
2گروه ژنتیک، واحد شهرکرد، دانشگاه آزاد اسلامی، شهرکرد، ایران
Abstract
Introduction: Colorectal cancer is becoming a more severe health and financial issue. The composition of the intestinal microbiota may be altered by colorectal cancer if Lactobacilli, Bacteroidetes, and Bifidobacteria abundance decreases. Herbal extracts and physical exercise can alter the amount of good bacteria and metabolite synthesis in the gut. Training with exercise can be useful in the primary prevention of cancer. Green unicellular microalgae called Chlorella vulgaris have long been used as food, particularly in Asia. They are rich in various functional components, such as proteins, fatty acids, polysaccharides, vitamins, and minerals.
Methods: To induce colorectal cancer, 3% DSS was received for seven days and then returned to normal drinking. Mice were divided into Five groups (n=30), including Control mice, mice treated with 3% DSS to induced colorectal cancer (CoCa group), CoCa mice received Paclitaxel, CoCa mice performed aerobic training with moderate intensity, CoCa mice received Chlorella vulgaris, CoCa mice performed aerobic training along with Chlorella vulgaris. Bacterial abundance was analyzed using Real-Time qPCR.
Results: The relative abundance of A. muciniphila, Bifidobacterium, F. prausnitzii, and Bacteroidetes was reduced in the CoCa group. Moreover, the relative abundance of Firmicutes was amplified. In contrast, aerobic training along with Chlorella vulgaris improved the relative abundance of A. muciniphila, Bifidobacterium, and F. prausnitzii, Bacteroidetes. Notably, the Paclitaxel had a negative effect on intestinal microbiota.
Conclusion: The aerobic training and Chlorella vulgaris ameliorated the relative abundance of A. muciniphila, Bifidobacterium, F. prausnitzii, and Bacteroidetes. Furthermore, aerobic training and Chlorella vulgaris reduced the relative abundance of Firmicutes.
Methods: To induce colorectal cancer, 3% DSS was received for seven days and then returned to normal drinking. Mice were divided into Five groups (n=30), including Control mice, mice treated with 3% DSS to induced colorectal cancer (CoCa group), CoCa mice received Paclitaxel, CoCa mice performed aerobic training with moderate intensity, CoCa mice received Chlorella vulgaris, CoCa mice performed aerobic training along with Chlorella vulgaris. Bacterial abundance was analyzed using Real-Time qPCR.
Results: The relative abundance of A. muciniphila, Bifidobacterium, F. prausnitzii, and Bacteroidetes was reduced in the CoCa group. Moreover, the relative abundance of Firmicutes was amplified. In contrast, aerobic training along with Chlorella vulgaris improved the relative abundance of A. muciniphila, Bifidobacterium, and F. prausnitzii, Bacteroidetes. Notably, the Paclitaxel had a negative effect on intestinal microbiota.
Conclusion: The aerobic training and Chlorella vulgaris ameliorated the relative abundance of A. muciniphila, Bifidobacterium, F. prausnitzii, and Bacteroidetes. Furthermore, aerobic training and Chlorella vulgaris reduced the relative abundance of Firmicutes.
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