Oral Presentation

Paper ID : 2030-SSRC

¹دانشگاه گیلان

²استاد، فیزیولوژی ورزشی، دانشکده تربیت بدنی و علوم ورزشی، دانشگاه گیلان، رشت، ایران.

One of the widely accepted techniques for inducing hypoxia is through the reduction of ambient oxygen levels or pressure. This method is preferred as it is considered to be a standard method with minimal or no side effects. To reduce the oxygen level or pressure of the environment, various equipment (masks, tents, and hypoxia rooms) have been made; most of this equipment is designed for human studies. The altitude simulator is specially designed for rodents to perform treatments related to hypoxia. The vacuum pumps of this device allow the researchers to reduce the oxygen pressure as it occurs at altitude. Pressure changes are regularly monitored by sensors with an accuracy of 1 millibar. The results showed that in the simulation at the height of 4500 meters with a pressure equal to 433 mm of mercury, the Coefficient of dispersion and relative error were 0.105 and 0.142, respectively. In this device, isobaric hypoxia was simulated by reducing the percentage of oxygen inside the chamber with an accuracy of 0.1%. In order to prevent gas gradients, the air inside is flowed by a fan. CO2 and indoor air humidity were absorbed using soda lime and silica gel chemical adsorbents. This device boasts an impressive set of capabilities that make it an excellent tool for laboratory studies. With the ability to regulate light-dark cycles, it ensures that experiments are conducted under consistent conditions. The device also enables the observation of rodents at night using red light, which is not disruptive to their behavior than other types of light. Additionally, it records environmental variables with precision, allowing for accurate analysis of the effects of various factors on experimental outcomes.

hypoxia; Altitude Simulator; Hypobaric; Isobaric