Poster Presentation

Paper ID : 2096-SSRC

¹دانشگاه شهیدبهشتی

²Department of Biological Sciences in Sport, Faculty of Sport Sciences and Health, Shahid Beheshti University, Tehran, Iran

³Abbas Haghparast: Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran School of Cognitive Sciences, Institute for Research in Fundamental Sciences, Tehran, Iran Department of Basic Sciences, Iranian Academy of Medical Sciences, Tehran, Iran

⁴Department of sport science, Faculty of social science, Imam Khomeini International University, Qazvin, Iran.

Methamphetamine is a common drug of abuse worldwide. This drug is highly addictive and leads to dangerous physical, mental, and psychological consequences. Many studies have been conducted to find an effective treatment for addiction. Recently, long-term exercise has been recognized as an effective therapeutic approach for addiction, as exercise reduces drug consumption and addiction, such as methamphetamine, by creating a protective effect. However, it is not clear whether long-term exercise training prevents addiction to effective doses of METH. This study comprised an experimental investigation involving 48 male Wistar rats. The rats were divided into six groups: C S , C METH1, C METH2, T S, T METH1, and T METH2. The exercise groups were subjected to eight weeks of compulsory running wheel at moderate intensity (65% of maximum speed), with three exercise sessions per week and durations ranging from 10 to 60 minutes in the final week. Following the training intervention, the METH1 groups received a dosage of one mg/kg and the METH2 groups receiving a dosage of two mg/kg underwent the conditioned place preference (CPP) model during the acquisition phase. Saline was also injected into CS and TS groups. The CPP score for each group was used to evaluate the drug's effectiveness and addictive potential of METH. The results of this study demonstrated conditioning in the control groups, METH1 and METH2, indicating addiction development. However, CPP scores of the training groups showed that exercise training is able to provide protective effects against addiction at a dose of 1mg/kg. Specifically, there was no significant difference in CPP score between the METH1 training group and the saline control group, indicating only in the exercise group METH2 was conditioning and addiction induced with a lower CPP score compared to the control group METH2 (P<0.05). Therefore, long-term exercise training was able to prevent the addiction caused by METH. Physical training can be an appropriate approach to combat addiction and its associated harms. It is necessary to examine it in various training protocols.

Addiction; Forced Running Wheel; Methamphetamine; Inhibition