Sirtuin 6 Gene Expression And Telomere Length Changes In Old Rat Hepatocytes After HIIT Swimming Exercise And Resveratrol Supplementation Feeding
Oral Presentation
Paper ID : 2105-SSRC
Authors
1مدرس دانشگاه آزاد اسلامی واحد بین المللی فرشتگان گروه تربیت بدنی
2استاد تمام گروه فیزیولوژی ورزشی دانشکده تربیت بدنی و علوم ورزشی دانشگاه تهران
3دانشیار گروه فیزیولوژی ورزشی دانشکده تربیت بدنی و علوم ورزشی دانشگاه تهران
Abstract
Abstract
Background :Aging is a complex phenomenon that is associated with a gradual decrease in physiological function and an increase in mortality, which often occurs as a result of many pathological diseases. telomere erosion is considered to be the main cause of aging
Aims: The present study aimed to determine the interactive effect of High intense interval training and resveratrol consumption on telomere length and expression sirtuin 6 genes of hepatocytes in elderly rats.
Materials & Methods:25 Wistar male rats were divided into 5 groups. 1.control that did not exercise. 2.the solvent that received the only solvent. 3. exercise activity that swam 20 seconds with 10 seconds rest in 6 weeks and 3 sessions per week. 4. supplement group that received resveratrol 10 ml/kg per day. 5. Combination of exercise and supplement that uses Combination exercise and supplement. for data analysis used One-way analysis of variance, tukey tests, and SPSS25 software.
Results: Resveratrol consumption and exercise significantly increased telomere length compared to control in order (P=0.000,0.001) and solvent (p=0.007,0.004). The expression of the sirtuin 6 gene was not affected by resveratrol (0.984), while exercise increased the expression of the sirtuin 6 gene(0.013). The combination of resveratrol supplementation and exercise did not double telomere length (0.395) and sirtuin 6 expression (0.502).
Conclusion: The interaction of very High-intensity interval training and resveratrol supplementation does not double the expression of the sirtuin 6 gene and telomere length of old rat liver cells. The molecular mechanism for slowing telomere erosion is probably complex and unaffected by concurrent interventions.
Background :Aging is a complex phenomenon that is associated with a gradual decrease in physiological function and an increase in mortality, which often occurs as a result of many pathological diseases. telomere erosion is considered to be the main cause of aging
Aims: The present study aimed to determine the interactive effect of High intense interval training and resveratrol consumption on telomere length and expression sirtuin 6 genes of hepatocytes in elderly rats.
Materials & Methods:25 Wistar male rats were divided into 5 groups. 1.control that did not exercise. 2.the solvent that received the only solvent. 3. exercise activity that swam 20 seconds with 10 seconds rest in 6 weeks and 3 sessions per week. 4. supplement group that received resveratrol 10 ml/kg per day. 5. Combination of exercise and supplement that uses Combination exercise and supplement. for data analysis used One-way analysis of variance, tukey tests, and SPSS25 software.
Results: Resveratrol consumption and exercise significantly increased telomere length compared to control in order (P=0.000,0.001) and solvent (p=0.007,0.004). The expression of the sirtuin 6 gene was not affected by resveratrol (0.984), while exercise increased the expression of the sirtuin 6 gene(0.013). The combination of resveratrol supplementation and exercise did not double telomere length (0.395) and sirtuin 6 expression (0.502).
Conclusion: The interaction of very High-intensity interval training and resveratrol supplementation does not double the expression of the sirtuin 6 gene and telomere length of old rat liver cells. The molecular mechanism for slowing telomere erosion is probably complex and unaffected by concurrent interventions.
Keywords