Serotonin-induced fatigue in central nervous system: Effect of a running session at heart rate deflection point (HRDP)
Poster Presentation
Paper ID : 2134-SSRC
Authors
1Professor of Exercise Physiology, Department of Physical Education and Sport Sciences, Faculty of Humanities, Tarbiat Modares University, Tehran, Iran.
2Ph.D. student of Exercise Physiology, Department of Physical Education and Sport Sciences, Faculty of Humanities, Tarbiat Modares University, Tehran, Iran
Abstract
Background: Probably, the central nervous system is one of the sites where fatigue occurs. The focus might be on the neurotransmitter serotonin [5-hydroxytryptamine (5-HT)]. Serotonin plays an important role in causing central fatigue during exercise, so that training to the point of exhaustion increases the release of serotonin and ultimately causes central fatigue. The purpose of this research was to investigate the effect of a running session at the HRDP on serotonin-induced fatigue in female students.
Methods: In this semi-experimental study, 14 female students with an average age of 24.66 ± 3.29 years, height 164.52±11.66 cm, and weight 60.56±12.42 kg participated voluntarily in this research. The fatiguing protocol of this study was running at the HRDP level until exhaustion. HRDP is defined as the heart rate deviation point from the straight line in examining the relationship between workload and heart rate, which is used as a criterion for planning the intensity of aerobic exercises. In general, the current research had two protocols. The first protocol was to determine the HRDP for each subject and the second protocol (exhaustion protocol) was to run at the HRDP level until reaching the limit of exhaustion. Both protocols were performed on a treadmill. Serum serotonin was measured between the pre-test and post-test phases using a serotonin kit (DLD, made in Germany). In order to compare and analyze the data, T-correlation software (SPSS) version 25 was used. A significance level of P≥0.05 was considered.
Results: The average serotonin of female runner athletes before training and immediately after training was 142.15±82.51, 240.26±94.67 (ng/ml), respectively; The results showed that there is a significant difference between the level of serotonin before training and immediately after training (P=0.021).
Conclusion: Obviously, fatigue is a very complex structure and brain neurochemistry can play a role in its initiation. In this study, fatigue during one session exercise was associated with an increase in the brain level of 5-HT. It can be concluded that the increase of brain 5-HT levels may be effective in determining the onset of fatigue during exhaustive exercise which may has effects on a training protocol in advance.
Methods: In this semi-experimental study, 14 female students with an average age of 24.66 ± 3.29 years, height 164.52±11.66 cm, and weight 60.56±12.42 kg participated voluntarily in this research. The fatiguing protocol of this study was running at the HRDP level until exhaustion. HRDP is defined as the heart rate deviation point from the straight line in examining the relationship between workload and heart rate, which is used as a criterion for planning the intensity of aerobic exercises. In general, the current research had two protocols. The first protocol was to determine the HRDP for each subject and the second protocol (exhaustion protocol) was to run at the HRDP level until reaching the limit of exhaustion. Both protocols were performed on a treadmill. Serum serotonin was measured between the pre-test and post-test phases using a serotonin kit (DLD, made in Germany). In order to compare and analyze the data, T-correlation software (SPSS) version 25 was used. A significance level of P≥0.05 was considered.
Results: The average serotonin of female runner athletes before training and immediately after training was 142.15±82.51, 240.26±94.67 (ng/ml), respectively; The results showed that there is a significant difference between the level of serotonin before training and immediately after training (P=0.021).
Conclusion: Obviously, fatigue is a very complex structure and brain neurochemistry can play a role in its initiation. In this study, fatigue during one session exercise was associated with an increase in the brain level of 5-HT. It can be concluded that the increase of brain 5-HT levels may be effective in determining the onset of fatigue during exhaustive exercise which may has effects on a training protocol in advance.
Keywords