Poster Presentation

Paper ID : 2154-SSRC

¹پژوهشگر پسادکتری فیزیولوژی ورزشی، گروه فیزیولوژی ورزشی، دانشکده علوم انسانی و اجتماعی، دانشگاه کردستان، سنندج، کردستان، ایران.

²دانشیار فیزیولوژی ورزشی، گروه فیزیولوژی ورزشی، دانشکده علوم انسانی و اجتماعی، دانشگاه کردستان، سنندج، ایران

Cardiovascular diseases (CVDs) include a group of common disorders that affect the heart and its blood vessels through various diseases such as hypertension, atherosclerosis, cardiomyopathy, myocardial ischemia and reperfusion injury. It has increased the number of deaths worldwide. Recently, researchers have focused on various strategies to treat cardiovascular diseases, including the autophagy process. As an evolutionarily conserved degradation pathway, autophagy plays an essential role in maintaining cellular homeostasis, protein turnover, and organelle recycling, which allows cells to adapt to nutrient deficiency and cellular stress and promote survival. Autophagy activation occurs in energy stress conditions such as energy restriction, obesity and increased physical activity. The present review study was conducted with the aim of investigating the effects of exercise training and its related mechanisms in regulating autophagy in cardiovascular diseases. In the present study, the desired articles were received through databases including CDSR, PROSPERO and CENTRAL. Studies highlight the emerging role of autophagy in exercise-induced cardiovascular benefits. As a unique physiological stress, regular exercise training plays an essential role in improving cardiovascular health through stimulating adaptive reactions. Autophagy seems to play an important role in this process. Exercise-induced autophagy selectively (mitophagy) targets specific cellular components such as mitochondria for destruction and recycling. Autophagy levels may vary based on exercise intensity. For example, low-intensity exercise training may increase autophagy, while high-intensity exercise training (HIIT) may decrease it. Endurance training has been shown to increase autophagy in cardiac muscle, and HIIT has been shown to increase baseline autophagic adaptation in cardiac muscle and help improve exercise capacity, as improvements associated with HIIT are associated with improved mitochondrial function and autophagic adaptation. it is related. In summary, exercise training and autophagy regulation are intricately linked in maintaining cardiac health. Regular exercise training, along with balanced autophagy, contributes to a flexible cardiovascular system. Although scientific evidence supports the regulation of cardiac autophagy caused by exercise training, the exact molecular mechanisms in this field are still one of the active areas of research.

Aerobic training; Macro- Autophagy; Cellular homeostasis; Cardiomyopathy