The effect of 12-weeks resistance training on some vasodilators and vasoconstrictors in hypertensive men
Poster Presentation
Paper ID : 2196-SSRC
Authors
دانشگاه آزاد اسلامی واحد ارس
Abstract
Background and aims: Primary hypertension, an unexplained increase in blood pressure (BP), accounts for 90% of the cases of hypertension and remains a critical public health challenge. Exercise training is a key non-pharmacological treatment for hypertension. In recent years, resistance training (RT) recommended alongside aerobic exercise training as an effective tool for decreasing BP. This study aimed to investigate the effects of 12-week resistance training on blood pressure, apelin, ANP, endothelin-1 (ET-1) and H2O2 in hypertensive men.
Methods: This is a semi-experimental study. A total of 40 middle-aged men (45.3±3.2 years) with moderate hypertension (systolic BP [SBP] 140.5±0.3 and diastolic BP [DBP] 90.7±0.0 mm Hg) were randomly divided into the RT (n=20) and non-exercise control (n=20) groups. The 12-week dynamic RT program was performed at an intensity of 80% of one repetition maximum for 3 days per week (3 sets of 8 repetitions/3 days a week). Blood samples were taken from both groups at baseline and weeks 4, 8, and 12.
Results: SBP and DBP decreased by -8.19±2.46 mm Hg (P=0.039) and -1.19±0.02 mm Hg (P=0.033) from baseline at week 12 in the RT group, respectively, compared to the control group (SBP; 8.22±2.49, P=0.04; DBP; -1.19±0.03, P=0.032). Apelin and atrial natriuretic peptide (ANP) serum levels increased from baseline at weeks 8 (P=0.01) and 12 (P=0.01). While endothelin-1 (ET-1) and H2O2 decreased from baseline at weeks 8 (P=0.01) and 12 (P=0.01) in the RT in comparison to the control group.
Conclusion: Overall, 12-week RT led to an increase in apelin and ANP. Increasing these markers reduces H2O2 and ET-1, thus decreasing SBP and DBP in hypertensive men.
Methods: This is a semi-experimental study. A total of 40 middle-aged men (45.3±3.2 years) with moderate hypertension (systolic BP [SBP] 140.5±0.3 and diastolic BP [DBP] 90.7±0.0 mm Hg) were randomly divided into the RT (n=20) and non-exercise control (n=20) groups. The 12-week dynamic RT program was performed at an intensity of 80% of one repetition maximum for 3 days per week (3 sets of 8 repetitions/3 days a week). Blood samples were taken from both groups at baseline and weeks 4, 8, and 12.
Results: SBP and DBP decreased by -8.19±2.46 mm Hg (P=0.039) and -1.19±0.02 mm Hg (P=0.033) from baseline at week 12 in the RT group, respectively, compared to the control group (SBP; 8.22±2.49, P=0.04; DBP; -1.19±0.03, P=0.032). Apelin and atrial natriuretic peptide (ANP) serum levels increased from baseline at weeks 8 (P=0.01) and 12 (P=0.01). While endothelin-1 (ET-1) and H2O2 decreased from baseline at weeks 8 (P=0.01) and 12 (P=0.01) in the RT in comparison to the control group.
Conclusion: Overall, 12-week RT led to an increase in apelin and ANP. Increasing these markers reduces H2O2 and ET-1, thus decreasing SBP and DBP in hypertensive men.
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